Validation Data Gallery
Product Information
IFNgCys2 is an unconjugated recombinant anti IFNg Nanobody (VHH). Suitable for for dual cysteine conjugation with thiol-reactive reagents, e.g. maleimides. Note: unconjugated VHHs are not suited for usage without prior labeling, since they contain reactive Cysteines. Shipment and storage buffers contain TCEP to keep Cysteines reduced.
Applications | Conjugation |
Reactivity | Human |
Conjugate | Unconjugated |
Type | Nanobody |
Class | Recombinant |
Host | Alpaca |
Affinity | Picomolar range, below the assay limit (biolayer interferometry) |
Molecular Weight | 14.8 kDa |
Form | Liquid |
RRID | AB_3665383 |
Storage Buffer | 10 mM HEPES pH 7.0, 500 mM NaCl, 0.09% sodium azide |
Storage Condition | Store at -20°C |
Shipping | dry ice |
Background | IFN gamma (IFNG) is a soluble cytokine that is the only member of the type II class of IFN. It is secreted by Th1 cells, cytotoxic T cells and NK cells. The cytokine is associated with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. It plays crucial roles in pathogen clearance. Aberrant IFNG expression is associated with a number of autoinflammatory and autoimmune diseases. It has been identified in many studies as a biomarker for pleural tuberculosis (TB). |