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Species Reactivity
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Conjugate
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Conjugate
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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

Validation Data Gallery

  • BLI analysis of the interaction between varying concentrations of anti-OSM VHH and immobilised, biotinylated HumanKine OSM (HZ-1030). Fit indicates fitting of data to a 1:1 binding model.

    BLI analysis of the interaction between varying concentrations of anti-OSM VHH and immobilised, biotinylated HumanKine OSM (HZ-1030). Fit indicates fitting of data to a 1:1 binding model.

ChromoTek anti-OSM recombinant VHH, for 1x Cys conjugation

osmCys1 is an unconjugated recombinant anti OSM Nanobody (VHH). Suitable for for cysteine conjugation with thiol-reactive reagents, e.g. maleimides. Note: unconjugated VHHs are not suited for usage without prior labeling, since they contain reactive Cysteines. Shipment and storage buffers contain TCEP to keep Cysteines reduced.
Cat No. osmCys1

Host/Type

Alpaca VHH

Reactivity

Human

Applications

Conjugation

Conjugate

Unconjugated

Synonyms

OSM-VHH, OSM single domain antibody (sdAb), OSM, Oncostatin-M

Size/Concentration: 

-/ -

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Product Information

osmCys1 is an unconjugated recombinant anti OSM Nanobody (VHH). Suitable for for cysteine conjugation with thiol-reactive reagents, e.g. maleimides. Note: unconjugated VHHs are not suited for usage without prior labeling, since they contain reactive Cysteines. Shipment and storage buffers contain TCEP to keep Cysteines reduced.

ApplicationsConjugation
ReactivityHuman
ConjugateUnconjugated
TypeNanobody
ClassRecombinant
HostAlpaca
Affinity120 nM
Molecular Weight13.9 kDa
FormLiquid
RRIDAB_3665414
Storage Buffer10 mM HEPES pH 7.0, 500 mM NaCl, 0.09% sodium azide
Storage ConditionStore at -20°C
Shippingdry ice
BackgroundOncostatin M (OSM) is a member of a cytokine family that includes a leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. OSM is a growth regulator which inhibits the proliferation of some tumor cell lines. It can stimulate proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF, and GM-CSF from endothelial cells. OSM is involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (PMID: 9133674; 29526757; 29363180; 21887386).