Validation Data Gallery
Product Information
CL555-IL6 is a recombinant CoraLite ® Plus 555 conjugated anti IL6 Nanobody (VHH) that targets IL6 in IF and FC applications, showing reactivity with human samples.
| Applications | IF, FC |
| Reactivity | Human |
| Conjugate | CoraLite® Plus 555 |
| Type | Nanobody |
| Class | Recombinant |
| Host | Alpaca |
| Affinity | 3 nM |
| Molecular Weight | 14.1 kDa |
| Form | Liquid |
| Excitation/Emission Maxima Wavelengths | 554 nm / 570 nm |
| RRID | AB_3665391 |
| Storage Buffer | 10 mM HEPES pH 7.0, 500 mM NaCl, 5 mM EDTA, 0.09% sodium azide |
| Storage Condition | Store at -20°C |
| Shipping | blue ice |
| Background | Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. IL-6 plays an essential role in the final differentiation of B-cells into Ig-secreting cells involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. IL-6 is also considered a myokine, a cytokine produced from muscle, and is elevated in response to muscle contraction. IL-6 has been shown to interact with interleukin-6 receptor and glycoprotein 130. Additionally, IL-6 is involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity. |
Documentation
| SDS |
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| CL555-IL6_SDS_anti-IL6 recombinant VHH, CoraLite® Plus 555 (EN) |