Validation Data Gallery
Product Information
IL34-b is a recombinant mono-biotinylated anti IL34 Nanobody (VHH), suitable for ELISA, SPR, and BLI applications.
| Applications | BLI, SPR, ELISA |
| Reactivity | Human |
| Conjugate | Biotin |
| Type | Nanobody |
| Class | Recombinant |
| Host | Alpaca |
| Affinity | 330 nM |
| Molecular Weight | 15.0 kDa |
| Form | Liquid |
| RRID | AB_3665405 |
| Storage Buffer | 10 mM HEPES pH 7.0, 500 mM NaCl, 5 mM EDTA, 0.09% sodium azide |
| Storage Condition | Store at -20°C |
| Shipping | ambient |
| Background | IL-34 is a 6-α-helix, proinflammatory cytokine that serves as a ligand for colony-stimulating factor-1 receptor (CSF1R). It is expressed most abundantly by spleen cells. It primarily stimulates human peripheral blood monocyte proliferation and macrophage colony formation. It is also required for Langerhans cell and microglia development. IL-34 has been shown to play a protective role in cancer and Alzheimer’s disease, but it can promote the progression of several autoimmune, inflammatory, and metabolic diseases. As such IL-34 could be used as a biomarker to mark the progression of these diseases (PMID: 22579672, 27577879, 31940023). |
Documentation
| SDS |
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| IL34-b_SDS_anti-IL34 recombinant VHH, biotinylated (EN) |