Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
67904-1-PBS targets WIF-1 in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag23972 Product name: Recombinant human WIF1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-180 aa of BC018037 Sequence: MARRSAFPAAALWLWSILLCLLALRAEAGPPQEESLYLWIDAHQARVLIGFEEDILIVSEGKMAPFTHDFRKAQQRMPAIPVNIHSMNFTWQAAGQAEYFYEFLSLRSLDKGIMADPTVNVPLLGTVPHKASVVQVGFPCLGKQDGVAAFEVDVIVMNSEGNTILKTPQNAIFFKTCQQA 相同性解析による交差性が予測される生物種 |
| Full Name | WNT inhibitory factor 1 |
| Calculated molecular weight | 42 kDa |
| Observed molecular weight | 41 kDa |
| GenBank accession number | BC018037 |
| Gene Symbol | WIF1 |
| Gene ID (NCBI) | 11197 |
| RRID | AB_2918660 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Protein G purification |
| UNIPROT ID | Q9Y5W5 |
| Storage Buffer | PBS only{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
Wnt inhibitory factor 1 (WIF-1), encoded by a highly conserved gene on human chromosome 12q14, is a critical extracellular morphogen antagonist. Structurally comprising a specialized WIF domain and five EGF-like repeats, this secreted protein aberration-proofs tissues by directly sequestering Wnt ligands. Consequently, it restrains downstream signaling during development and functions predominantly as an epigenetically silenced tumor suppressor. (PMID: 10201374; 19307728; 21743455).