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Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using SORBS2 Polyclonal antibody (24643-1-AP)

    WB analysis using 24643-1-AP (same clone as 24643-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 24643-1-AP (SORBS2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24643-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of U-251 cells using SORBS2 Polyclonal antibody (24643-1-AP)

    WB analysis of U-251 using 24643-1-AP (same clone as 24643-1-PBS)

    U-251 cells were subjected to SDS PAGE followed by western blot with 24643-1-AP (SORBS2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24643-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of MDCK cells using SORBS2 Polyclonal antibody (24643-1-AP)

    WB analysis of MDCK using 24643-1-AP (same clone as 24643-1-PBS)

    MDCK cells were subjected to SDS PAGE followed by western blot with 24643-1-AP (SORBS2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24643-1-PBS in a different storage buffer formulation.

  • Immunoprecipitation (IP) experiment of mouse heart tissue using SORBS2 Polyclonal antibody (24643-1-AP)

    IP experiment of mouse heart using 24643-1-AP (same clone as 24643-1-PBS)

    IP result of anti-SORBS2 (IP:24643-1-AP, 4ug; Detection:24643-1-AP 1:500) with mouse heart tissue lysate 4000ug. This data was developed using the same antibody clone with 24643-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human pancreas cancer tissue using SORBS2 Polyclonal antibody (24643-1-AP)

    IHC staining of human pancreas cancer using 24643-1-AP (same clone as 24643-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 24643-1-AP (SORBS2 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 24643-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of mouse heart tissue using SORBS2 Polyclonal antibody (24643-1-AP)

    IHC staining of mouse heart using 24643-1-AP (same clone as 24643-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse heart tissue slide using 24643-1-AP (SORBS2 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 24643-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of U2OS cells using SORBS2 Polyclonal antibody (24643-1-AP)

    IF Staining of U2OS using 24643-1-AP (same clone as 24643-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed U2OS cells using SORBS2 antibody (24643-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 24643-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

SORBS2 Polyclonal antibody, PBS Only

SORBS2 Polyclonal Antibody for WB, IHC, IF/ICC, IP, Indirect ELISA
Cat No. 24643-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, canine

Applications

WB, IHC, IF/ICC, IP, Indirect ELISA

Synonyms

Arg/Abl-interacting protein 2, Arg-binding protein 2, ArgBP2, Sorbin and SH3 domain-containing protein 2

Formulation:  PBS Only
PBS, Azide, Glycerol
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

24643-1-PBS targets SORBS2 in WB, IHC, IF/ICC, IP, Indirect ELISA applications and shows reactivity with human, mouse, canine samples.

Tested Reactivity human, mouse, canine
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen

CatNo: Ag20041

Product name: Recombinant human SORBS2 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-198 aa of BC011883

Sequence: MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDR

相同性解析による交差性が予測される生物種
Full Name sorbin and SH3 domain containing 2
Calculated molecular weight 1100 aa, 124 kDa
Observed molecular weight 70-75 kDa
GenBank accession numberBC011883
Gene Symbol SORBS2
Gene ID (NCBI) 8470
RRIDAB_2879652
Conjugate Unconjugated
Form
FormLiquid
Purification MethodAntigen affinity purification
UNIPROT IDO94875
Storage Buffer PBS only{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -80°C.

Background Information

SORBS2, also known as ARGBP2, has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. SORBS2 is widely expressed in human tissues and extremely abundant in the heart. In epithelial cells SORBS2 is located in stress fibers and the nucleus; In cardiac muscle cells. SORBS2 is located in the Z-disks of sarcomeres. The subcellular localization suggests that SORBS2 functions as an adapter protein to assemble signaling complexes in stress fibers, and may influence the contractile or elastic properties of cardiac sarcomeres(PMID: 9211900). Alternate splicing results in multiple transcript variants( PMID: 28961272).

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