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Validation Data Gallery

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  • Immunohistochemistry (IHC) staining of mouse brain tissue using SCN10A/Nav1.8 Polyclonal antibody (55334-1-AP)

    IHC staining of mouse brain using 55334-1-AP (same clone as 55334-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 55334-1-AP (SCN10A/Nav1.8 antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 55334-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of mouse brain tissue using SCN10A/Nav1.8 Polyclonal antibody (55334-1-AP)

    IHC staining of mouse brain using 55334-1-AP (same clone as 55334-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 55334-1-AP (SCN10A/Nav1.8 antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 55334-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of rat Ischiadic nerve tissue using SCN10A/Nav1.8 Polyclonal antibody (55334-1-AP)

    IHC staining of rat Ischiadic nerve using 55334-1-AP (same clone as 55334-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat Ischiadic nerve tissue slide using 55334-1-AP (SCN10A/Nav1.8 antibody) at dilution of 1:600 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 55334-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of rat Ischiadic nerve tissue using SCN10A/Nav1.8 Polyclonal antibody (55334-1-AP)

    IHC staining of rat Ischiadic nerve using 55334-1-AP (same clone as 55334-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat Ischiadic nerve tissue slide using 55334-1-AP (SCN10A/Nav1.8 antibody) at dilution of 1:600 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 55334-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of SH-SY5Y cells using SCN10A/Nav1.8 Polyclonal antibody (55334-1-AP)

    IF Staining of SH-SY5Y using 55334-1-AP (same clone as 55334-1-PBS)

    Immunofluorescent analysis of SH-SY5Y cells using 55334-1-AP (SCN10A/Nav1.8 antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 55334-1-PBS in a different storage buffer formulation.

  • Flow cytometry (FC) experiment of HeLa cells using SCN10A/Nav1.8 Polyclonal antibody (55334-1-AP)

    FC experiment of HeLa using 55334-1-AP (same clone as 55334-1-PBS)

    1X10^6 HeLa cells were intracellularly stained with 0.4 ug Anti-Human SCN10A/Nav1.8 (55334-1-AP) and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) at dilution 1:1000 (red), or 0.4 ug Isotype Control. Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer. This data was developed using the same antibody clone with 55334-1-PBS in a different storage buffer formulation.

SCN10A/Nav1.8 Polyclonal antibody, PBS Only

SCN10A/Nav1.8 Polyclonal Antibody for IHC, IF/ICC, FC (Intra), Indirect ELISA
Cat No. 55334-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

IHC, IF/ICC, FC (Intra), Indirect ELISA

Synonyms

SCN10A, hPN3, Nav1.8, PN3, SNS

Formulation:  PBS Only
PBS, Azide, Glycerol
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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約2万点のプロテインテック製品をコスモバイオ社物流センター（国内）に在庫しています。国内在庫の有無はコスモバイオ社ホームページの「品番検索」でカタログ番号を検索して確認できます。

保証・サポートについて

テクニカルサポートまたはご購入後1年間の交換／補填対応を承ります。詳細はこちらをご覧ください。

Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

55334-1-PBS targets SCN10A/Nav1.8 in IHC, IF/ICC, FC (Intra), Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen

Peptide

相同性解析による交差性が予測される生物種
Full Name sodium channel, voltage-gated, type X, alpha subunit
Calculated molecular weight 221 kDa
GenBank accession numberNM_006514
Gene Symbol SCN10A
Gene ID (NCBI) 6336
RRIDAB_2881309
Conjugate Unconjugated
Form
FormLiquid
Purification MethodAntigen affinity purification
UNIPROT IDQ9Y5Y9
Storage Buffer PBS only{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -80°C.

Background Information

Sodium channel protein type 10 subunit alpha (SCN10A, also known as Nav1.8) is predominantly expressed in neurons of the dorsal root ganglion (DRG) and trigeminal ganglion (PMID: 8538791; 9169448). Nav1.8 markedly modulates nociceptor excitability, and thereby participates in pain‑processing mechanisms (PMID: 20367448; 11495938). Furthermore, functional SCN10A/Nav1.8 has been detected in intracardiac neurons, revealing a previously unrecognized function of this neuronal sodium channel in the modulation of cardiac electrical activity (PMID: 22723301).

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