Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
86740-1-PBS targets RNF43 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse samples.
| Tested Reactivity | human, mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
CatNo: Eg6490 Product name: Recombinant Human RNF43 protein (rFc Tag) Source: mammalian cells-derived, V37 Tag: C-rFc Domain: 24-197 aa of NM_001305544.1 Sequence: GFGRTGLVLAAAVESERSAEQKAIIRVIPLKMDPTGKLNLTLEGVFAGVAEITPAEGKLMQSHPLYLCNASDDDNLEPGFISIVKLESPRRAPRPCLSLASKARMAGERGASAVLFDITEDRAAAEQLQQPLGLTWPVVLIWGNDAEKLMEFVYKNQKAHVRIELKEPPAWPDY 相同性解析による交差性が予測される生物種 |
| Full Name | ring finger protein 43 |
| Calculated molecular weight | 86 kDa |
| Observed molecular weight | 86 kDa |
| GenBank accession number | NM_001305544.1 |
| Gene Symbol | RNF43 |
| Gene ID (NCBI) | 54894 |
| RRID | AB_3745094 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | Q68DV7 |
| Storage Buffer | PBS only{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
RNF43 (ring finger protein 43) is a member of proteins of Goliath and Godzilla families, which bears the characteristic sequence of an ubiquitin ligase and of a trans-membrane region, encoding E3 ubiquitination kinase and with the activity of E3 ubiquitin protein ligase. RNF43 has attracted much attention in the study of Wnt/β-catenin signaling pathway because of its high structural homology with ZNRF3(zinc and ring finger protein 3). RNF43 inhibits Wnt/β-catenin signalling by ubiquitinating Frizzled receptor and targeting it to the lysosomal pathway for degradation.