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Validation Data Gallery

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  • Immunofluorescence (IF) / fluorescent staining of HeLa cells using CoraLite® Plus 488-conjugated PQBP1 Recombinant an (CL488-84491-6)

    IF Staining of HeLa using CL488-84491-6

    Immunofluorescent analysis of (4% PFA) fixed HeLa cells using CoraLite® Plus 488 PQBP1 antibody (CL488-84491-6, Clone: 241901B11 ) at dilution of 1:200, CL594-Phalloidin (red).

［PR］まずは試したいあなたに。トライアルサイズも特別価格 >>『PRIME BUY抗体特割キャンペーン（4/21～）』

CoraLite® Plus 488-conjugated PQBP1 Recombinant antibody

PQBP1 Uni-rAbTM Recombinant Antibody for IF/ICC
Cat No. CL488-84491-6
Clone No.241901B11

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

Synonyms

241901B11, Npw38, Polyglutamine tract-binding protein 1, Polyglutamine-binding protein 1, PQBP-1

Formulation:  PBS and Azide
PBS and Azide
Conjugate:  CoraLite® Plus 488
Size/Concentration: 

-/ -

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Tested Applications

Positive IF/ICC detected inHeLa cells

Recommended dilution

ApplicationDilution
Immunofluorescence (IF)/ICCIF/ICC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

CL488-84491-6 targets PQBP1 in applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen PQBP1 fusion protein Ag9329 相同性解析による交差性が予測される生物種
Full Name polyglutamine binding protein 1
Calculated molecular weight 265 aa, 30 kDa
Observed molecular weight 30-32 kDa
GenBank accession numberBC012358
Gene Symbol PQBP1
Gene ID (NCBI) 10084
Conjugate CoraLite® Plus 488 Fluorescent Dye
Excitation/Emission maxima wavelengths493 nm / 522 nm
Form Liquid
Purification MethodProtein A purification
UNIPROT IDO60828
Storage Buffer PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

PQBP1 (Polyglutamine-binding protein 1) is also named as NPW38 and JM26. PQBP1 senses extrinsic tau 3R/4R proteins by direct interaction and triggers an innate immune response by activating a cyclic GMP-AMP synthase (cGAS)-Stimulator of interferon genes (STING) pathway (PMID: 34782623).  PQBP1 is abundantly expressed in the central nervous system during development. PQBP1 is a component of the precatalytic spliceosome (B complex) that is involved in splicing. PQBP1 was predominantly localized in the cell nucleus. PQBP1 is overexpressed in various cancer types including breast cancer, colon cancer, and glioblastoma (PMID: 38342602).

Protocols

Product Specific Protocols
IF protocol for CL Plus 488 PQBP1 antibody CL488-84491-6Download protocol
Standard Protocols
Click here to view our Standard Protocols