Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
32301-1-PBS targets OIT3 in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag36932 Product name: Recombinant human OIT3 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 297-506 aa of NM_152635.2 Sequence: VSNGTHVNILFSLKTCGTVVDVVNDKIVASNLVTGLPKQTPGSSGDFIIRTSKLLIPVTCEFPRLYTISEGYVPNLRNSPLEIMSRNHGIFPFTLEIFKDNEFEEPYREALPTLKLRDSLYFGIEPVVHVSGLESLVESCFATPTSKIDEVLKYYLIRDGCVSDDSVKQYTSRDHLAKHFQVPVFKFVGKDHKEVFLHCRVLVCGVLDER 相同性解析による交差性が予測される生物種 |
| Full Name | oncoprotein induced transcript 3 |
| Calculated molecular weight | 60 kDa，545aa |
| Observed molecular weight | 70 kDa |
| GenBank accession number | NM_152635.2 |
| Gene Symbol | OIT3 |
| Gene ID (NCBI) | 170392 |
| RRID | AB_3742572 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Antigen affinity Purification |
| UNIPROT ID | Q8WWZ8 |
| Storage Buffer | PBS only{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
Oncoprotein-induced transcript 3 protein (OIT3) is a liver-specific protein. It is involved in various biological processes, including lipid metabolism and ferroptosis regulation. OIT3 has been shown to mediate macrophage polarization and facilitate hepatocellular carcinoma (HCC) progression by regulating the arachidonic acid metabolism and reactive oxygen species (ROS) accumulation (PMID: 35353239). Additionally, OIT3 is implicated in the regulation of lipid metabolism, particularly in the context of triacylglycerol and very low-density lipoproteins (VLDLs) in the liver (PMID: 36132142).