Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
84165-5-PBS targets IL-7 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
Product name: HumanKine® recombinant human IL-7 protein Source: -derived, Tag: Sequence: 相同性解析による交差性が予測される生物種 |
| Full Name | interleukin 7 |
| Gene Symbol | IL-7 |
| Gene ID (NCBI) | 3574 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | P13232 |
| Storage Buffer | PBS only{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
Interleukin-7 (IL-7) is a non-redundant, pleiotropic cytokine fundamental to the development, homeostasis, and function of the immune system. It is primarily produced by stromal cells in the bone marrow and thymus, as well as by epithelial cells in peripheral lymphoid organs. IL-7 signals through a heterodimeric receptor consisting of the private IL-7 receptor alpha chain (IL-7Rα/CD127) and the common gamma chain (γc), activating key pathways such as JAK/STAT, PI3K/Akt, and MAPK to promote lymphocyte survival, proliferation, and metabolic fitness. Its critical role is underscored by the severe lymphopenia and immunodeficiency observed in both IL-7- and IL-7R-deficient humans and mice.