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Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using IFN-gamma R2 Polyclonal antibody (10266-1-AP)

    WB analysis using 10266-1-AP (same clone as 10266-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 10266-1-AP (IFNGR2 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 10266-1-PBS in a different storage buffer formulation.

  • Immunoprecipitation (IP) experiment of A549 cells using IFN-gamma R2 Polyclonal antibody (10266-1-AP)

    IP experiment of A549 using 10266-1-AP (same clone as 10266-1-PBS)

    IP result of anti-IFNGR2 (IP:10266-1-AP, 4ug; Detection:10266-1-AP 1:500) with A549 cells lysate 1800ug. This data was developed using the same antibody clone with 10266-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human breast cancer tissue using IFN-gamma R2 Polyclonal antibody (10266-1-AP)

    IHC staining of human breast cancer using 10266-1-AP (same clone as 10266-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 10266-1-AP (IFNGR2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 10266-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human breast cancer tissue using IFN-gamma R2 Polyclonal antibody (10266-1-AP)

    IHC staining of human breast cancer using 10266-1-AP (same clone as 10266-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 10266-1-AP (IFNGR2 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 10266-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of A549 cells using IFN-gamma R2 Polyclonal antibody (10266-1-AP)

    IF Staining of A549 using 10266-1-AP (same clone as 10266-1-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed A549 cells using IFN-gamma R2 antibody (10266-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 10266-1-PBS in a different storage buffer formulation.

IFN-gamma R2 Polyclonal antibody, PBS Only

IFN-gamma R2 Polyclonal Antibody for WB, IHC, IF/ICC, IP, Indirect ELISA
Cat No. 10266-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, IF/ICC, IP, Indirect ELISA

Synonyms

IFNGR2, AF 1, AF-1, IFGR2, IFN gamma R2

Formulation:  PBS Only
PBS, Azide, Glycerol
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

10266-1-PBS targets IFN-gamma R2 in WB, IHC, IF/ICC, IP, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen

CatNo: Ag0317

Product name: Recombinant human IFNGR2 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 126-324 aa of BC003624

Sequence: WVTMPWFQHYRNVTVGPPENIEVTPGEGSLIIRFSSPFDIADTSTAFFCYYVHYWEKGGIQQVKGPFRSNSISLDNLKPSRVYCLQVQAQLLWNKSNIFRVGHLSNISCYETMADASTELQQVILISVGTFSLLSVLAGACFFLVLKYRGLIKYWFHTPPSIPLQIEEYLKDPTQPILEALDKDSSPKDDVWDSVSIIS

相同性解析による交差性が予測される生物種
Full Name interferon gamma receptor 2 (interferon gamma transducer 1)
Calculated molecular weight 45 kDa
Observed molecular weight 50-55 kDa
GenBank accession numberBC003624
Gene Symbol IFNGR2
Gene ID (NCBI) 3460
RRIDAB_2121709
Conjugate Unconjugated
Form
FormLiquid
Purification MethodAntigen affinity purification
UNIPROT IDP38484
Storage Buffer PBS only{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -80°C.

Background Information

Interferon-gamam (IFN-γ) is a cytokine critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Cellular responses to IFN-γ are activated through its interaction with a heterodimeric receptor consisting of two subunits, IFNGR1 and IFNGR2. IFNGR1 is the ligand-binding subunit which binds IFN-γ with high affinity, whereas IFNGR2 serves as the accessory subunit which attaches to IFN-γ with a significantly lower affinity. Two subunits bind one IFN-γ dimer. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. (PMID: 17981204; 946248; 10888113)

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