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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

CoraLite®594-conjugated Endoglin/CD105 Monoclonal antibody

Endoglin/CD105 Monoclonal Antibody for IF

Host / Isotype

Mouse / IgG2b

Reactivity

Human

Applications

IF

Conjugate

CoraLite®594 Fluorescent Dye

CloneNo.

2D5E8

Cat no : CL594-67075

Synonyms

CD105, END, endoglin, Endoglin/CD105, ENG, FLJ41744, HHT1, ORW, ORW1

Validation Data Gallery

Applications:
  • IF Staining of human breast cancer using CL594-67075

    IF Staining of human breast cancer using CL594-67075

    Immunofluorescent analysis of (4% PFA) fixed human breast cancer tissue using CoraLite®594 Endoglin/CD105 antibody (CL594-67075, Clone: 2D5E8 ) at dilution of 1:200.

  • IF Staining of human breast cancer using CL594-67075

    IF Staining of human breast cancer using CL594-67075

    Immunofluorescent analysis of (4% PFA) fixed human breast cancer tissue using CoraLite®594 Endoglin/CD105 antibody (CL594-67075, Clone: 2D5E8 ) at dilution of 1:200.

Tested Applications

Positive IF detected inhuman breast cancer tissue
For other applications, we recommend the unconjugated version of this antibody, 67075-1-Ig

Recommended dilution

ApplicationDilution
Immunofluorescence (IF)IF : 1:50-1:500
Sample-dependent, check data in validation data gallery

Product Information

CL594-67075 targets Endoglin/CD105 in IF applications and shows reactivity with Human samples.

Tested Reactivity Human
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Immunogen Endoglin/CD105 fusion protein Ag27837 相同性解析による交差性が予測される生物種
Full Name endoglin
Calculated molecular weight 71 kDa
Observed molecular weight 95-100 kDa
GenBank accession numberBC014271
Gene symbol ENG
Gene ID (NCBI) 2022
RRIDAB_2920083
Conjugate CoraLite®594 Fluorescent Dye
Excitation/Emission maxima wavelengths588 nm / 604 nm
Form Liquid
Purification Method Protein A purification
Storage Buffer PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
Storage ConditionsStore at -20°C. Avoid exposure to light. Aliquoting is unnecessary for -20oC storage.

Background Information

Endoglin (ENG, CD105) is a homodimeric cell membrane glycoprotein of 180 kDa, composed of disulphide-linked subunits of 95 kDa. Endoglin is a proliferation-associated and hypoxia-inducible protein mainly expressed on vascular endothelial cells. It acts as an accessory receptor for transforming growth factor beta (TFG-β) and is involved in vascular development and remodelling. The important role of Endoglin in angiogenesis and in tumor progression makes it an ideal target for antiangiogenic therapy and a good marker for tumor prognosis. (PMID: 1326540; 14528280; 21737653; 12773481)

Protocols

Product Specific Protocols
IF protocol for CL594 Endoglin/CD105 antibody CL594-67075Download protocol
Standard Protocols
Click here to view our Standard Protocols