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Validation Data Gallery

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  • Western Blot (WB) analysis of mouse liver tissue using CYP1A1 Recombinant monoclonal antibody (88462-1-RR)

    WB analysis of mouse liver using 88462-1-RR (same clone as 88462-1-PBS)

    mouse liver tissue were subjected to SDS PAGE followed by western blot with 88462-1-RR (CYP1A1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 88462-1-PBS in a different storage buffer formulation.

  • WB analysis of mouse lung using 88462-1-RR

    WB analysis of mouse lung using 88462-1-RR

    mouse lung tissue were subjected to SDS PAGE followed by western blot with 88462-1-RR (CYP1A1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours.

  • Western Blot (WB) analysis of rat liver tissue using CYP1A1 Recombinant monoclonal antibody (88462-1-RR)

    WB analysis of rat liver using 88462-1-RR (same clone as 88462-1-PBS)

    rat liver tissue were subjected to SDS PAGE followed by western blot with 88462-1-RR (CYP1A1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 88462-1-PBS in a different storage buffer formulation.

CYP1A1 Recombinant monoclonal antibody, PBS Only

CYP1A1 Uni-rAb® Recombinant Antibody for WB, Indirect ELISA
Cat No. 88462-1-PBS
Clone No.261000F5

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

Synonyms

AHH, AHRR, CP11, CYP1, CYPIA1

Formulation:  PBS Only
PBS, Azide, Glycerol
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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保証・サポートについて

テクニカルサポートまたはご購入後1年間の交換／補填対応を承ります。詳細はこちらをご覧ください。

Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

88462-1-PBS targets CYP1A1 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen

CatNo: Ag3990

Product name: Recombinant human CYP1A1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 115-465 aa of BC023019

Sequence: ISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARW

相同性解析による交差性が予測される生物種
Full Name cytochrome P450, family 1, subfamily A, polypeptide 1
Calculated molecular weight 512 aa, 58 kDa
Observed molecular weight 50-58 kDa
GenBank accession numberBC023019
Gene Symbol CYP1A1
Gene ID (NCBI) 1543
Conjugate Unconjugated
Form
FormLiquid
Purification MethodProtein A purification
UNIPROT IDP04798
Storage Buffer PBS only{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -80°C.

Background Information

CYP1A1 is a phase I xenobiotic-metabolizing enzyme that bioactivates environmental procarcinogens, particularly polycyclic aromatic hydrocarbons (PAHs), into reactive intermediates that can initiate carcinogenesis. Its expression is primarily regulated at the transcriptional level by the aryl hydrocarbon receptor (AHR), which upon ligand binding induces CYP1A1 via xenobiotic response elements. Genetic polymorphisms in the human CYP1A1 gene have been linked to increased susceptibility to lung and other cancers.

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