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Validation Data Gallery

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  • Western Blot (WB) analysis of HepG2 cells using CREB5 Polyclonal antibody (14196-1-AP)

    WB analysis of HepG2 using 14196-1-AP (same clone as 14196-1-PBS)

    HepG2 cells were subjected to SDS PAGE followed by western blot with 14196-1-AP (CREB5 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14196-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of HeLa cells using CREB5 Polyclonal antibody (14196-1-AP)

    WB analysis of HeLa using 14196-1-AP (same clone as 14196-1-PBS)

    HeLa cells were subjected to SDS PAGE followed by western blot with 14196-1-AP (CREB5 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14196-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of MCF-7 cells using CREB5 Polyclonal antibody (14196-1-AP)

    WB analysis of MCF-7 using 14196-1-AP (same clone as 14196-1-PBS)

    MCF7 cells were subjected to SDS PAGE followed by western blot with 14196-1-AP (CREB5 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14196-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of human brain tissue using CREB5 Polyclonal antibody (14196-1-AP)

    WB analysis of human brain using 14196-1-AP (same clone as 14196-1-PBS)

    human brain tissue were subjected to SDS PAGE followed by western blot with 14196-1-AP (CREB5 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14196-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

CREB5 Polyclonal antibody, PBS Only

CREB5 Polyclonal Antibody for WB, Indirect ELISA
Cat No. 14196-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

CRE-BPa, CREBPA, CREB-5, CREB 5, cAMP-responsive element-binding protein 5

Formulation:  PBS Only
PBS, Azide, Glycerol
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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保証・サポートについて

テクニカルサポートまたはご購入後1年間の交換／補填対応を承ります。詳細はこちらをご覧ください。

Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

14196-1-PBS targets CREB5 in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen

CatNo: Ag5399

Product name: Recombinant human CREB5 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 1-369 aa of BC059400

Sequence: MFCTSGGNSASVMSMRPVPGSLSSLLHLHNRQRQPMPASMPGTLPNPTMPGSSAVLMPMERQMSVNSSIMGMQGPNLSNPCASPQVQPMHSEAKMRLKAALTHHPAAMSNGNMNTMGHMMEMMGSRQDQTPHHHMHSHPHQHQTLPPHHPYPHQHQHPAHHPHPQPHHQQNHPHHHSHSHLHAHPAHHQTSPHPPLHTGNQAQVSPATQQMQPTQTIQPPQPTGGRRRRVVDEDPDERRRKFLERNRAAATRCRQKRKVWVMSLEKKAEELTQTNMQLQNEVSMLKNEVAQLKQLLLTHKDCPITAMQKESQGYLSPESSPPASPVPACSQQQVIQHNTITTSSSVSEVVGSSTLSQLTTHRTDLNPIL

相同性解析による交差性が予測される生物種
Full Name cAMP responsive element binding protein 5
Calculated molecular weight 57 kDa
Observed molecular weight 57 kDa
GenBank accession numberBC059400
Gene Symbol CREB5
Gene ID (NCBI) 9586
RRIDAB_2083832
Conjugate Unconjugated
Form
FormLiquid
Purification MethodAntigen affinity purification
UNIPROT IDQ02930
Storage Buffer PBS only{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -80°C.

Background Information

cyclic AMP responsive element binding protein 5 (CREB5), also known as CRE-BPA, a member of the cAMP response element binding protein family, is a transcription factor specifically expressed in superficial zone articular chondrocytes and is required for TGF-β and EGFR signaling. Knockdown of CREB5 decreased the c-jun and c-fos expression levels in HC-a cells (PMID: 38549717). Increased CREB5 expression is positively correlated with tumor cell invasion and a poor prognosis for cancer patients with epithelial ovarian cancer and hepatocellular carcinoma (PMID: 38418476).This protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified (PMID: 33712729).

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