Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
33453-1-PBS targets C4orf32 in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag38764 Product name: Recombinant human C4orf32 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-99 aa of BC022534 Sequence: MCSAGELLRGGDGGERDEDGDALAEREAAGTEWDPGASQRRRGQRQKESEQDVEDSQNHTGEPVGDDYKKMGTLFGELNKNLINMGFTRMYFGERIVEP 相同性解析による交差性が予測される生物種 |
| Full Name | chromosome 4 open reading frame 32 |
| Observed molecular weight | 20 kDa |
| GenBank accession number | BC022534 |
| Gene Symbol | C4orf32 |
| Gene ID (NCBI) | 132720 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Antigen affinity Purification |
| UNIPROT ID | Q8N8J7 |
| Storage Buffer | PBS only{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
The FAM241A protein, also known as C4orf32, is a key regulatory factor that is localized to the Golgi apparatus. It plays an important role in maintaining the structural integrity of the Golgi apparatus and is involved in processes such as protein glycosylation and vesicle transport. More importantly, FAM241A has been identified as a novel negative regulator of the Hippo signaling pathway. It directly binds to and inhibits the activity of the core kinases MST1/2, thereby relieving the suppression of the downstream effectors YAP/TAZ, promoting cell proliferation, and inhibiting apoptosis. Aberrant function of FAM241A is closely related to the occurrence and development of various human diseases, especially tumors, making it a highly promising target for basic research and clinical translation.