Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
88168-3-PBS targets ACD as part of a matched antibody pair:
MP03378-1: 88168-3-PBS capture and 88168-2-PBS detection (validated in Cytometric bead array, Sandwich ELISA)
Unconjugated rabbit recombinant monoclonal antibody in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation. Created using Proteintech’s proprietary in-house recombinant technology. Recombinant production enables unrivalled batch-to-batch consistency, easy scale-up, and future security of supply.
This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
CatNo: Ag23021 Product name: Recombinant human ACD protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-351 aa of BC016904 Sequence: MPGRCQSDAAMRVNGPASRAPAGWTSGSLHTGPRAGRPRAQARGVRGRGLLLRPRPAKELPLPRKGGAWAPAGNPGPLHPLGVAVGMAGSGRLVLRPWIRELILGSETPSSPRAGQLLEVLQDAEAAVAGPSHAPDTSDVGATLLVSDGTHSVRCLVTREALDTSDWEEKEFGFRGTEGRLLLLQDCGVHVQVAEGGAPAEFYLQVDRFSLLPTEQPRLRVPGCNQDLDVQKKLYDCLEEHLSESTSSNAGLSLSQLLDEMREDQEHQGALVCLAESCLTLEGPCTAPPVTHWAASRCKATGEAVYTVPSSMLCISENDQLILSSLGPCQRTQGPELPPPDPALQDLSLTL 相同性解析による交差性が予測される生物種 |
| Full Name | adrenocortical dysplasia homolog (mouse) |
| Calculated molecular weight | 58 kDa |
| Observed molecular weight | 60 kDa |
| GenBank accession number | BC016904 |
| Gene Symbol | ACD |
| Gene ID (NCBI) | 65057 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | Q96AP0 |
| Storage Buffer | PBS only{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
ACD (Adrenocortical Dysplasia Homolog), also known as TPP1 or POT1- and TIN2-Organizing Protein, is a core component of the telomeric Shelterin complex. It participates in telomere length maintenance, telomere structural protection, and regulation of genomic stability. Together with POT1, TIN2, TRF1, TRF2, RAP1, and TIN2, ACD assembles into the Shelterin complex, which coats telomeric DNA, suppresses DNA damage response and telomere fusion, and prevents chromosome ends from being recognized as DNA double-strand breaks. Mutations in the ACD gene cause Dyskeratosis Congenita, Hoyeraal-Hreidarsson syndrome, and bone marrow failure syndromes, and are closely associated with telomerase dysfunction.