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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

CoraLite® Plus 488-conjugated cIAP1 Monoclonal antibody

cIAP1 Monoclonal Antibody for IF

Host / Isotype

Mouse / IgG1

Reactivity

Human, mouse, rat, pig

Applications

IF

Conjugate

CoraLite® Plus 488 Fluorescent Dye

CloneNo.

1H3F1

Cat no : CL488-66626

Synonyms

API1, BIRC2, C IAP1, cIAP1, Hiap 2, HIAP2, IAP 2, IAP homolog B, IAP2, MIHB, RING finger protein 48, RNF48

Validation Data Gallery

Applications:
  • IF Staining of HepG2 using CL488-66626

    IF Staining of HepG2 using CL488-66626

    Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using CoraLite® Plus 488 cIAP1 antibody (CL488-66626, Clone: 1H3F1 ) at dilution of 1:100.

Tested Applications

Positive IF detected inHepG2 cells
Planning an IHC experiment? We recommend our IHCeasy BIRC2/cIAP1 Ready-To-Use IHC Kit. BIRC2/cIAP1 primary antibody included.
For other applications, we recommend the unconjugated version of this antibody, 66626-1-Ig

Recommended dilution

ApplicationDilution
Immunofluorescence (IF)IF : 1:50-1:500
Sample-dependent, check data in validation data gallery

Product Information

CL488-66626 targets cIAP1 in IF applications and shows reactivity with Human, mouse, rat, pig samples.

Tested Reactivity Human, mouse, rat, pig
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen cIAP1 fusion protein Ag21398 相同性解析による交差性が予測される生物種
Full Name baculoviral IAP repeat-containing 2
Calculated molecular weight 618 aa, 70 kDa
GenBank accession numberBC016174
Gene symbol BIRC2
Gene ID (NCBI) 329
RRIDAB_2919353
Conjugate CoraLite® Plus 488 Fluorescent Dye
Excitation/Emission maxima wavelengths493 nm / 522 nm
Form Liquid
Purification Method Protein G purification
Storage Buffer PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
Storage ConditionsStore at -20°C. Avoid exposure to light. Aliquoting is unnecessary for -20oC storage.

Background Information

BIRC2 (also known as cIAP1) is a member of the inhibitor of apoptosis protein (IAP) family. The inhibitor of apoptosis (IAP) proteins are a family of anti-apoptotic regulators found in viruses and metazoans. BIRC2 is a nuclear shuttling protein, whose subcellular localization is mediated by the CRM1-dependent nuclear export pathway (PMID: 15265700). The protein is regulated transcriptionally and can be inhibited by mitochondrial proteins released in the cytoplasm upon apoptotic stimuli (PMID: 15187025). BIRC2 is also believed to be a critical regulator of vascular integrity and endothelial cell survival, thereby providing an additional target pathway for the control of angiogenesis and blood vessel homeostasis during embryogenesis, regeneration and tumorigenesis (PMID: 17934460).

Protocols

Product Specific Protocols
IF protocol for CL Plus 488 cIAP1 antibody CL488-66626Download protocol
Standard Protocols
Click here to view our Standard Protocols