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CoraLite®488 Endoglin/CD105 抗体 0 文献

Mouse Monoclonal| カタログ番号: CL488-67075 |クローン番号: 2D5E8

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適用アプリケーション

アプリケーション:
FC
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Endoglin/CD105 Antibody FC HUVEC cells CL488-67075

1X10^6 HUVEC cells were stained with 0.2 ug CoraLite®488 Anti-Human Endoglin/CD105 (CL488-67075, Clone: 2D5E8) (green), or 0.2 ug CoraLite®488 mouse IgG2b isotype control (black). Cells were fixed with 90% MeOH.

種特異性:
Human
FC ポジティブ:
HUVEC cells
推奨希釈倍率:
Excitation/Emission maxima wavelengths:
488 nm/515 nm

Protocols

Product-specific protocols

Standard Protocols

製品情報

由来:
Mouse
精製方法:
Protein A purification
アイソタイプ:
IgG2b
バッファー/保存方法:
PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. Store at -20oC. Avoid exposure to light. Aliquoting is unnecessary for -20oC storage.

ターゲット情報

免疫原:
Endoglin/CD105 fusion protein Ag27837
正式名:
endoglin
計算分子量:
71 kDa
検出分子量:
95-100 kDa
GenBank accession number:
BC014271
Gene ID (NCBI):
2022
遺伝子シンボル:
ENG
別名:
CD105, END, endoglin, ENG, FLJ41744, HHT1, ORW, ORW1

背景説明

Endoglin (ENG, CD105) is a homodimeric cell membrane glycoprotein of 180 kDa, composed of disulphide-linked subunits of 95 kDa. Endoglin is a proliferation-associated and hypoxia-inducible protein mainly expressed on vascular endothelial cells. It acts as an accessory receptor for transforming growth factor beta (TFG-β) and is involved in vascular development and remodelling. The important role of Endoglin in angiogenesis and in tumor progression makes it an ideal target for antiangiogenic therapy and a good marker for tumor prognosis. (PMID: 1326540; 14528280; 21737653; 12773481)


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