• HEK293 expressed
  • Endotoxin-free
  • Animal-component free

HumanKine® recombinant human VEGF121 protein

Activity

Typically ≤ 15 ng/mL EC50

Species Reactivity

human,pig,mouse

Purity

>95%

Cat no : HZ-1204

Synonyms

L VEGFA, MVCD1, Vascular permeability factor, VEGF, VEGF A, VEGF121, VEGFA, VPF



Technical Specifications

GeneID 7422
Species Human
Expression HEK293
Activity Typically ≤ 15 ng/mL EC50
Purity >95%
Endotoxin<1 EU/µg
Accession NumberP15692
Molecular Mass 37 kDa, homodimer; 50 kDa, homotrimer, glycosylated
Formulation 1x PBS, See Certificate of Analysis for details
Species Reactivity human,pig,mouse

Stability and Reconstitution

Stability and Storage Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1xPBS pH 7.4 containing 0.1% endotoxin-free recombinant human serum albumin (HSA).

Background

This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulphide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells and is essential for physiological and pathological angiogenesis. Misregulations of this gene in mice result in abnormal embryonic blood vessel formation (PMID:10838264; 11329058).

Synonyms

L VEGFA, MVCD1, Vascular permeability factor, VEGF, VEGF A, VEGF121, VEGFA, VPF

Publications

SpeciesTitle
mouse,human

Circ Res

Esm1 modulates endothelial tip cell behavior and vascular permeability by enhancing VEGF bioavailability.

Authors - Susana FRocha
human

J Clin Invest

Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice.

Authors - YokoFukushima

Nat Commun

DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously.

Authors - Roland Beckmann
human

Elife

Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells.

Authors - NathanKumar
human

Oncogene

Progranulin and granulin-like protein as novel VEGF-independent angiogenic factors derived from human mesothelioma cells.

Authors - REguchi
human

Protein Cell

CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-κB/RelA in maintaining the homeostasis of human vascular cells.

Authors - Ping Wang