- HEK293 expressed
- Endotoxin-free
- Animal-component free
HumanKine® recombinant human TGF beta 3 protein
Activity
0.01 - 0.2 ng/mL
Specific Activity
minimally 1.00 x 107 IU/mg
Species Reactivity
human,mouse
Purity
>95%
Cat no : HZ-1090
Synonyms
ARVD, FLJ16571, TGF beta 3, TGF beta3, TGFB3
Validation Data Gallery
Technical Specifications
| GeneID | 7043 |
| Species | Human |
| Expression | HEK293 |
| Activity | 0.01 - 0.2 ng/mL |
| Specific Activity | minimally 1.00 x 107 IU/mg |
| Purity | >95% |
| Endotoxin | <1 EU/µg |
| Accession Number | P17125 |
| Molecular Mass | 13 kDa reduced, 22 kDa non-reduced, homodimer, non-glycosylated |
| Formulation | 50 mM NaOAc pH 3.7 + 1% CHAPS, See Certificate of Analysis for details |
| Species Reactivity | human,mouse |
Stability and Reconstitution
| Stability and Storage | Product Form | Temperature Conditions | Storage Time (From Date of Receipt) |
|---|---|---|---|
| Lyophilized | -20°C to -80°C | Until Expiry Date | |
| Lyophilized | Room Temperature | 2 weeks | |
| Reconstituted as per CofA | -20°C to -80°C | 6 months | |
| Reconstituted as per CofA | 4°C | 1 week | |
| Avoid repeated freeze-thaw cycles. | |||
| Reconstitution | Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein to 0.1mg/mL in sterile 4 mM HCl containing 0.1% endotoxin-free recombinant human serum albumin (HSA). Gently swirl or tap vial to mix. |
Background
The transforming growth factor beta-3 (TGFβ-3) protein is found throughout the body and is required for development before birth and throughout life. TGFβ-3 binds to the receptor proteins on the surface of cells. This binding triggers the transmission of signals within the cell. As part of the TGF-β a signalling pathway, the TGFβ-3 protein helps to control the growth and cell proliferation. The TGFβ-3 protein is especially abundant in skeletal muscles and plays a key role in their development. The protein is also involved in blood vessels formation, regulation of bone growth, and wound healing (PMID: 25835445; 23824657)
Synonyms
ARVD, FLJ16571, TGF beta 3, TGF beta3, TGFB3
Publications
| Species | Title |
|---|---|
J Control Release Picoliter ice particles by supersonic cryogenic jets for transdermal drug delivery: Extracellular vesicle application for skin diseases. | |
Cell Commun Signal Short-term response of primary human meniscus cells to simulated microgravity | |
J Tissue Eng Non-hypertrophic chondrogenesis of mesenchymal stem cells through mechano-hypoxia programing | |
Stem Cell Res Ther Enhanced lubricin secretion by human synovial mesenchymal stem cells compared to adipose mesenchymal stem cells. | |
Neurotherapeutics Bioreactor-produced iPSCs-derived dopaminergic neuron-containing neural microtissues innervate and normalize rotational bias in a dose-dependent manner in a Parkinson rat model. | |
Cells Suitability of Ex Vivo-Expanded Microtic Perichondrocytes for Auricular Reconstruction |