Mouse p21 Monoclonal antibody, PBS Only
p21 Monoclonal Antibody for IF, ELISA
Host / Isotype
Mouse / IgG2b
Reactivity
mouse
Applications
IF, ELISA
Conjugate
Unconjugated
CloneNo.
3C7D3
Cat no : 67362-1-PBS
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| Sample-dependent, check data in validation data gallery | |
Product Information
67362-1-PBS targets p21 in IF, ELISA applications and shows reactivity with mouse samples.
| Tested Reactivity | mouse |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | p21 fusion protein Ag28394 相同性解析による交差性が予測される生物種 |
| Full Name | cyclin-dependent kinase inhibitor 1A (P21) |
| Calculated molecular weight | 18 kDa |
| GenBank accession number | NM_001111099 |
| Gene symbol | Cdkn1a |
| Gene ID (NCBI) | 12575 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| Storage Buffer | PBS only |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
CDKN1A (p21, CIP1, WAF1) is a cyclin-dependent kinase inhibitor. CDKN1A binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at the G1 phase. The expression of CDKN1A is induced by wild-type but not mutant p53 protein, through which CDKN1A mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. CDKN1A can interact with proliferating cell nuclear antigen (PCNA), and plays a regulatory role in S phase DNA replication and DNA damage repair. CDKN1A was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation.
