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Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using p120 Catenin Recombinant monoclonal antibody (88083-1-RR)

    WB analysis using 88083-1-RR (same clone as 88083-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 88083-1-RR (CTNND1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. Low expression: HL-60 cells. This data was developed using the same antibody clone with 88083-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human colon tissue using p120 Catenin Recombinant monoclonal antibody (88083-1-RR)

    IHC staining of human colon using 88083-1-RR (same clone as 88083-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 88083-1-RR (p120 Catenin antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 88083-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human colon tissue using p120 Catenin Recombinant monoclonal antibody (88083-1-RR)

    IHC staining of human colon using 88083-1-RR (same clone as 88083-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 88083-1-RR (p120 Catenin antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 88083-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of MCF-7 cells using p120 Catenin Recombinant monoclonal antibody (88083-1-RR)

    IF Staining of MCF-7 using 88083-1-RR (same clone as 88083-1-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed MCF-7 cells using p120 Catenin antibody (88083-1-RR, Clone: 260247D5 ) at dilution of 1:500 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 88083-1-PBS in a different storage buffer formulation.

p120 Catenin Recombinant monoclonal antibody, PBS Only

p120 Catenin Uni-rAb® Recombinant Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 88083-1-PBS
Clone No.260247D5

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, IF/ICC, Indirect ELISA

Synonyms

CTNND1, Cadherin-associated Src substrate, CAS, Catenin delta 1, Catenin delta-1

Formulation:  PBS Only
PBS, Azide, Glycerol
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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保証・サポートについて

テクニカルサポートまたはご購入後1年間の交換／補填対応を承ります。詳細はこちらをご覧ください。

Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

88083-1-PBS targets p120 Catenin in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen

CatNo: Ag2824

Product name: Recombinant human CTNND1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 546-830 aa of BC010501

Sequence: GYELLFQPEVVRIYISLLKESKTPAILEASAGAIQNLCAGRWTYGRYIRSALRQEKALSAIADLLTNEHERVVKAASGALRNLAVDARNKELIGKHAIPNLVKNLPGGQQNSSWNFSEDTVISILNTINEVIAENLEAAKKLRETQGIEKLVLINKSGNRSEKEVRAAALVLQTIWGYKELRKPLEKEGWKKSDFQVNLNNASRSQSSHSYDDSTLPLIDRNQKSDKKPDREEIQMSNMGSNTKSLDNNYSTPNERGDHNKTLDRSGDLGDMEPLKGTTPLMQKI

相同性解析による交差性が予測される生物種
Full Name catenin (cadherin-associated protein), delta 1
Calculated molecular weight 948 aa, 105 kDa
Observed molecular weight75-120 kDa
GenBank accession numberBC010501
Gene Symbol p120 Catenin
Gene ID (NCBI) 1500
Conjugate Unconjugated
Form
FormLiquid
Purification MethodProtein A purification
UNIPROT IDO60716
Storage Buffer PBS only{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -80°C.

Background Information

Catenins were discovered as proteins that are linked to the cytoplasmic domain of transmembrane cadherins (PMID: 9653641). p120 catenin, also called p120 ctn or catenin delta-1(CTNND1), regulates cell-cell adhesion through its interaction with the cytoplasmic tail of classical and type II cadherins. p120 catenin is a tyrosine kinase substrate implicated in cell transformation by SRC, as well as in ligand-induced receptor signaling through the EGF receptor, the PDGF receptor, and the CSF1 receptor. Different expression patterns of p120 catenin in lobular and ductal carcinomas of the breast have been reported: membrane stain for ductal carcinoma and cytoplasmic stain for lobular carcinoma (PMID: 24966968). Different isoforms of p120 catenin are variably expressed in different tissues as a result of alternative splicing and the use of multiple translation initiation codons (PMID: 19150613).

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