Validation Data Gallery
Tested Applications
| Positive WB detected in | A431 cells, HepG2 cells, SMMC-7221 cells |
Recommended dilution
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:500-1:1000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Product Information
32274-1-AP targets ZNF706 in WB, ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag37605 Product name: Recombinant human ZNF706 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-76 aa of BC015925 Sequence: MARGQQKIQSQQKNAKKQAGQKKKQGHDQKAAAKAALIYTCTVCRTQMPDPKTFKQHFESKHPKTPLPPELADVQA 相同性解析による交差性が予測される生物種 |
| Full Name | zinc finger protein 706 |
| Calculated molecular weight | 76 aa, 8 kDa |
| Observed molecular weight | 12 kDa |
| GenBank accession number | BC015925 |
| Gene Symbol | ZNF706 |
| Gene ID (NCBI) | 51123 |
| RRID | AB_3742562 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Antigen affinity Purification |
| UNIPROT ID | Q9Y5V0 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
Zinc Finger domains account for 5% of all human proteins and interact with various substrates, such as lipids, DNA, RNA, and post-translational modifications. In addition, zinc finger proteins (ZNFs) are involved in transcriptional regulation, signal transduction, and other cellular processes. Zinc finger protein 706 (ZNF706), encoded by a gene located at chromosome 8q22.3, is a member of the C2H2-type zinc finger transcription factor family, the most abundant transcription factor family encoded by the human genome. And according to the structural analysis of ZNF706, it was definitely predicted to physically bind to DNA through the C-terminal zinc finger domain. In previous studies, it was reported that the expression of ZNF706 is upregulated in gastric cancer and laryngeal cancer. And ZNF706 may be a biomarker for the early diagnosis of rheumatoid arthritis. ZNF706 is a potential oncogene in liver cancer and functions as a ferroptosis regulator by modulating SLC7A11 expression, constituting a potential therapeutic target for HCC (PMID: 38862581).
Protocols
| Product Specific Protocols | |
|---|---|
| WB protocol for ZNF706 antibody 32274-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |