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Validation Data Gallery

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  • Western Blot (WB) analysis of HeLa cells using TTI1 Polyclonal antibody (22381-1-AP)

    WB analysis of HeLa using 22381-1-AP (same clone as 22381-1-PBS)

    HeLa cells were subjected to SDS PAGE followed by western blot with 22381-1-AP (TTI1 antibody at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22381-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using TTI1 Polyclonal antibody (22381-1-AP)

    WB analysis using 22381-1-AP (same clone as 22381-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 22381-1-AP (TTI1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22381-1-PBS in a different storage buffer formulation.

  • Immunoprecipitation (IP) experiment of HeLa cells using TTI1 Polyclonal antibody (22381-1-AP)

    IP experiment of HeLa using 22381-1-AP (same clone as 22381-1-PBS)

    IP result of anti-TTI1 (IP:22381-1-AP, 4ug; Detection:22381-1-AP 1:1000) with HeLa cells lysate 1600ug. This data was developed using the same antibody clone with 22381-1-PBS in a different storage buffer formulation.

TTI1 Polyclonal antibody, PBS Only

TTI1 Polyclonal Antibody for WB, IP, Indirect ELISA
Cat No. 22381-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IP, Indirect ELISA

Synonyms

KIAA0406, Tel two interacting protein 1, TELO2-interacting protein 1 homolog

Formulation:  PBS Only
PBS, Azide, Glycerol
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

22381-1-PBS targets TTI1 in WB, IP, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen

CatNo: Ag17697

Product name: Recombinant human KIAA0406 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 740-1089 aa of BC013755

Sequence: DVLATLDQFYDKRAASFVSVLHALMAALAQWFPDTGNLGHLQEQSLGEEGSHLNQRPAALEKSTTTAEDIEQFLLNYLKEKDVADGNVSDFDNEEEEQSVPPKVDENDTRPDVEPPLPLQIQIAMDVMERCIHLLSDKNLQIRLKVLDVLDLCVVVLQSHKNQLLPLAHQAWPSLVHRLTRDAPLAVLRAFKVLRTLGSKCGDFLRSRFCKDVLPKLAGSLVTQAPISARAGPVYSHTLAFKLQLAVLQGLGPLCERLDLGEGDLNKVADACLIYLSVKQPVKLQEAARSVFLHLMKVDPDSTWFLLNELYCPVQFTPPHPSLHPVQLHGASGQQNPYTTNVLQLLKELQ

相同性解析による交差性が予測される生物種
Full Name KIAA0406
Calculated molecular weight 1089 aa, 122 kDa
Observed molecular weight 120 kDa
GenBank accession numberBC013755
Gene Symbol TTI1
Gene ID (NCBI) 9675
RRIDAB_2879094
Conjugate Unconjugated
Form
FormLiquid
Purification MethodAntigen Affinity purified
UNIPROT IDO43156
Storage Buffer PBS only{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -80°C.

Background Information

Telomere maintenance 2-interacting protein 1 (TTI1), also known as KIAA0406 or SMG10, is one of the members of the conserved Triple T (TTT) complex, which is composed of telo a regulator of DNA damage and repair. TTI1 is expressed in numerous organisms and is assumed to play a central role in regulating a wide spectrum of DNA damage responses, telomere maintenance, and checkpoint signaling (PMID: 20427287). Knockdown of Tti1 suppresses phosphorylation of both mTORC1 substrates (S6K1 and 4E-BP1) and an mTORC2 substrate (Akt) (PMID: 40514657)

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