DCT (L-dopachrome Delta-isomerase) is also named as TYRP2,TRP2 and belongs to the tyrosinase family. Human TYRP2 protein has 83% identity and 90% similarity to the mouse sequence and has all the structural characteristics of the tyrosinase protein family, including a signal peptide, 15 conserved cysteine residues, 2 copper-binding domains, and a C-terminal membrane-spanning region (PMID:8206391). TYRP2 is involved in neural progenitor cell proliferation and has been implicated in drug and radiation resistance in malignant melanoma. Mutations in DCT cause oculocutaneous albinism type VIII (OCA8), and TYRP2 serves as both an early melanoblast marker and a melanoma-associated antigen with clinical relevance as a potential biomarker in immune checkpoint therapy.