Validation Data Gallery
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Tested Applications
| Positive WB detected in | mouse kidney tissue |
Recommended dilution
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:500-1:1000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Product Information
24226-1-AP targets TMEM63B in WB, ELISA applications and shows reactivity with human, mouse samples.
| Tested Reactivity | human, mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag21573 Product name: Recombinant human TMEM63B protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 700-832 aa of BC136769 Sequence: TMRTGFLAPTSMFTFVVLVITIVICLCHVCFGHFKYLSAHNYKIEHTETDTVDPRSNGRPPTAAAVPKSAKYIAQVLQDSEVDGDGDGAPGSSGDEPPSSSSQDEELLMPPDALTDTDFQSCEDSLIENEIHQ 相同性解析による交差性が予測される生物種 |
| Full Name | transmembrane protein 63B |
| Calculated molecular weight | 832 aa, 95 kDa |
| Observed molecular weight | 95 kDa |
| GenBank accession number | BC136769 |
| Gene Symbol | TMEM63B |
| Gene ID (NCBI) | 55362 |
| RRID | AB_3085727 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Antigen Affinity purified |
| UNIPROT ID | Q5T3F8 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
TMEM63B, also known as C6orf110, belongs to the TMEM63 family. TMEM63B is a mechanosensitive cation channel activated by hypoosmotic stress and mechanic stimulation. Genetic deletion of TMEM63B is a cause of necroptosis of outer hair cells (OHCs) and progressive hearing loss (PMID: 32375046).
Protocols
| Product Specific Protocols | |
|---|---|
| WB protocol for TMEM63B antibody 24226-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |