Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
88228-1-PBS targets TMEM219 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
CatNo: Eg10278 Product name: Recombinant human TMEM219 protein Source: mammalian cells-derived, V37 Tag: C-rFc Domain: 39-204 aa of NM_001083613.2 Sequence: SFLLTHRTGLRSPDIPQDWVSFLRSFGQLTLCPRNGTVTGKWRGSHVVGLLTTLNFGDGPDRNKTRTFQATVLGSQMGLKGSSAGQLVLITARVTTERTAGTCLYFSAVPGILPSSQPPISCSEEGAGNATLSPRMGEECVSVWSHEGLVLTKLLTSEELALCGSR 相同性解析による交差性が予測される生物種 |
| Full Name | transmembrane protein 219 |
| Calculated molecular weight | 26 kDa |
| Observed molecular weight | 26~30 kDa |
| GenBank accession number | NM_001083613.2 |
| Gene Symbol | TMEM219 |
| Gene ID (NCBI) | 124446 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | Q86XT9 |
| Storage Buffer | PBS only{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
TMEM219, also known as IGFBP-3R (Insulin-like growth factor-binding protein 3 receptor), is a recently discovered death receptor, which induces cell apoptosis by a Caspase-8-dependent mechanism, through the binding with its ligand, the Insulin-like growth factors binding protein 3 (IGFBP3). TMEM219 was one of the most highly expressed and ranked the third most abundant beta-cell receptor. Increased TMEM219 expression was primarily evident in intestinal cells cultured with inflammatory cytokines and it was associated with higher cell death