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Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using TMEM120A Polyclonal antibody (17455-1-AP)

    WB analysis using 17455-1-AP (same clone as 17455-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 17455-1-AP (TMEM120A antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17455-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of HEK-293 cells using TMEM120A Polyclonal antibody (17455-1-AP)

    WB analysis of HEK-293 using 17455-1-AP (same clone as 17455-1-PBS)

    WB result of TMEM120A antibody (17455-1-AP; 1:2400; incubated at room temperature for 1.5 hours) with sh-Control and sh-TMEM120A transfected HEK-293 cells. This data was developed using the same antibody clone with 17455-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of HeLa cells using TMEM120A Polyclonal antibody (17455-1-AP)

    IF Staining of HeLa using 17455-1-AP (same clone as 17455-1-PBS)

    Immunofluorescent analysis of HeLa cells using 17455-1-AP (TMEM120A antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 17455-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

TMEM120A Polyclonal antibody, PBS Only

TMEM120A Polyclonal Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 17455-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IF/ICC, Indirect ELISA

Synonyms

Ion channel TACAN, NET29, TACAN, TMPIT, Transmembrane protein 120A

Formulation:  PBS Only
PBS, Azide, Glycerol
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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保証・サポートについて

テクニカルサポートまたはご購入後1年間の交換／補填対応を承ります。詳細はこちらをご覧ください。

Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

17455-1-PBS targets TMEM120A in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen

CatNo: Ag10849

Product name: Recombinant human TMEM120A protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 1-322 aa of BC029487

Sequence: MQPPPPGPLGDCLRDWEDLQQDFQNIQETHRLYRLKLEELTKLQNNCTSSITRQKKRLQELALALKKCKPSLPAEAEGAAQELENRMKERQGLFFDMEAYLPKKNGLYLSLVLGNVNVTLLSKQAKFAYKDEYEKFKLYLTIILILISFTCRFLLNSRVTDAAFNFLLVWYYCTLTIRESILINNGSRWAGRALREGSMEWGARTLREAGTGAGGDGGSLLQDQRLVGVPSLRVHLPVGSHADVVRRSHVPEIPEPIPLLFHVPELRAVSPVLLPERLPLPPAGAGRAAHHGPHCGGLPVLDVAGPHLPAAFSFLWTLLAAF

相同性解析による交差性が予測される生物種
Full Name transmembrane protein 120A
Calculated molecular weight 322 aa, 36 kDa, 41 kDa
Observed molecular weight 35 kDa
GenBank accession numberBC029487
Gene Symbol TMEM120A
Gene ID (NCBI) 83862
RRIDAB_2204630
Conjugate Unconjugated
Form
FormLiquid
Purification MethodAntigen affinity purification
UNIPROT IDQ9BXJ8
Storage Buffer PBS only{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -80°C.

Background Information

TMEM120A (also known as TACAN) is a nuclear envelope transmembrane protein essential for adipocyte differentiation and lipid metabolism. Originally identified through proteomic screening, it regulates spatial genome organization by repositioning pro-adipogenic genes from the nuclear periphery to the interior during adipogenesis. Adipocyte-specific knockout mice exhibit lipodystrophy with insulin resistance. TMEM120A was initially proposed as a mechanosensitive ion channel involved in mechanical pain sensing; however, subsequent structural studies revealed it contains a coenzyme A-binding site and shares homology with fatty acid elongases, challenging its role as an ion channel (PMID: 26024229; 34409941; 34374645).

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