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Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using TMCO1 Polyclonal antibody (27757-1-AP)

    WB analysis using 27757-1-AP (same clone as 27757-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 27757-1-AP (TMCO1 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27757-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human intrahepatic cholangiocarcinoma tissue using TMCO1 Polyclonal antibody (27757-1-AP)

    IHC staining of human intrahepatic cholangiocarcinoma using 27757-1-AP (same clone as 27757-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human intrahepatic cholangiocarcinoma tissue slide using 27757-1-AP (TMCO1 antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27757-1-PBS in a different storage buffer formulation.

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TMCO1 Polyclonal antibody, PBS Only

TMCO1 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 27757-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, Indirect ELISA

Synonyms

UNQ151/PRO177, TMCC4, RP11 466F5.7, PNAS 136, PCIA3

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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約2万点のプロテインテック製品をコスモバイオ社物流センター（国内）に在庫しています。国内在庫の有無はコスモバイオ社ホームページの「品番検索」でカタログ番号を検索して確認できます。

保証・サポートについて

テクニカルサポートまたはご購入後1年間の交換／補填対応を承ります。詳細はこちらをご覧ください。

Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

27757-1-PBS targets TMCO1 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen TMCO1 fusion protein Ag26278 相同性解析による交差性が予測される生物種
Full Name transmembrane and coiled-coil domains 1
Calculated molecular weight 21 kDa
Observed molecular weight 21 kDa
GenBank accession numberNM_019026
Gene Symbol TMCO1
Gene ID (NCBI) 54499
RRIDAB_2880962
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ9UM00
Storage Buffer PBS only , pH 7.3
Storage ConditionsStore at -80°C.

Background Information

TMCO1, also known as TMCC4, PNAS-10, and PNAS-136, is a 188 amino acid protein, which is Widely expressed in adult and fetal tissues, with higher levels in thymus, prostate, testis and small intestine and lower levels in brain, placenta, lung and kidney (PubMed:10393320, PubMed:20018682). TMCO1 as a Calcium-selective channel is required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis (PubMed:27212239). In response to endoplasmic reticulum overloading, TMCO1, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store (PubMed:27212239).