TDP-43 Polyclonal antibody
TDP-43 Polyclonal Antibody for ELISA
Host / Isotype
Rabbit / IgG
Reactivity
Human, Mouse
Applications
ELISA
Conjugate
Unconjugated
Cat no : 27841-1-AP
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
Sample-dependent, check data in validation data gallery |
Product Information
27841-1-AP targets TDP-43 in ELISA applications and shows reactivity with Human, Mouse samples.
Tested Reactivity | Human, Mouse |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | TDP-43 fusion protein Ag26155 相同性解析による交差性が予測される生物種 |
Full Name | TAR DNA binding protein |
Calculated molecular weight | 43 kDa |
Observed molecular weight | 37-40 kDa |
GenBank accession number | BC001487 |
Gene symbol | TARDBP |
Gene ID (NCBI) | 23435 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
TDP-43 is a DNA and RNA-binding protein which regulates transcription and splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. TDP-43 can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat and stabilize the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR. Besides, it may also be involved in microRNA biogenesis, apoptosis and cell division. 27841-1-AP is a rabbit polyclonal antibody recognises the 37-40 kDa protein because of the cleaved fragments and posttranslationally modification.