Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
87509-1-PBS targets TCR α/β in WB, IHC, Indirect ELISA applications and shows reactivity with human, rat samples.
| Tested Reactivity | human, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
CatNo: Eg9184 Product name: Recombinant human TCR α/β protein Source: mammalian cells-derived, pHZ-KIsec-C-6*HIS Tag: C-6*HIS Sequence: TRAC IQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPSPESSCDVKLVEKSFETDTNLNFQNLS 1-115 TRBC DLKNVFPPKVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADCGFTSESYQQGVLSA 1-144 相同性解析による交差性が予測される生物種 |
| Full Name | TCR α/β |
| Observed molecular weight | 35 kDa |
| Gene Symbol | |
| Gene ID (NCBI) | |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Protein A purification |
| Storage Buffer | PBS only{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
TCR α/β (T-cell receptor α/β heterodimer) is a core molecule of the adaptive immune system, formed by the disulfide bond linkage of α and β transmembrane polypeptide chains. It is present on the surface of most mature T cells and non-covalently associates with the CD3 complex to form the complete T-cell receptor (TCR-CD3 complex). Its primary function is to recognize antigen peptides presented by major histocompatibility complex (MHC) molecules. The genes encoding TCR α/β undergo V(D)J recombination, generating an extraordinarily high degree of diversity, enabling the immune system to recognize a vast array of antigens. TCR α/β plays a decisive role in T-cell development, activation, clonal selection, and immune responses, making it a fundamental target in immunology research and a key molecule in tumor immunotherapy, such as TCR-T therapy.