Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Product Information
16859-1-AP targets SYCE2-Specific in ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
Peptide 相同性解析による交差性が予測される生物種 |
| Full Name | synaptonemal complex central element protein 2 |
| Calculated molecular weight | 25 kDa |
| Observed molecular weight | 50 kDa |
| GenBank accession number | NM_001105578 |
| Gene Symbol | SYCE2 |
| Gene ID (NCBI) | 256126 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q6PIF2 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
SYCE2 (synaptonemal complex central element protein 2) is a structural component of the synaptonemal complex (SC) that is essential for meiotic chromosome synapsis and homologous recombination during meiosis. SYCE2 localizes to the central element of the synaptonemal complex, where it interacts with other SC proteins, including SYCE1, SYCE3, and TEX12, to promote assembly and stabilization of the central region. Through these interactions, SYCE2 facilitates homologous chromosome pairing, meiotic crossover formation, and accurate chromosome segregation, thereby ensuring normal gametogenesis and fertility. Deficiency or mutation of SYCE2 disrupts synaptonemal complex formation, resulting in defective meiosis, germ cell apoptosis, and infertility.