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Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using SOCS6 Polyclonal antibody (27343-1-AP)

    WB analysis using 27343-1-AP (same clone as 27343-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 27343-1-AP (SOCS6 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27343-1-PBS in a different storage buffer formulation.

  • Immunoprecipitation (IP) experiment of NIH/3T3 cells using SOCS6 Polyclonal antibody (27343-1-AP)

    IP experiment of NIH/3T3 using 27343-1-AP (same clone as 27343-1-PBS)

    IP result of anti-SOCS6 (IP:27343-1-AP, 4ug; Detection:27343-1-AP 1:1500) with NIH/3T3 cells lysate 1200 ug. This data was developed using the same antibody clone with 27343-1-PBS in a different storage buffer formulation.

  • Immunoprecipitation (IP) experiment of human placenta tissue using SOCS6 Polyclonal antibody (27343-1-AP)

    IP experiment of human placenta using 27343-1-AP (same clone as 27343-1-PBS)

    IP result of anti-SOCS6 (IP:27343-1-AP, 4ug; Detection:27343-1-AP 1:1500) with human placenta tissue lysate 960 ug. This data was developed using the same antibody clone with 27343-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human colon tissue using SOCS6 Polyclonal antibody (27343-1-AP)

    IHC staining of human colon using 27343-1-AP (same clone as 27343-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 27343-1-AP (SOCS6 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27343-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human colon tissue using SOCS6 Polyclonal antibody (27343-1-AP)

    IHC staining of human colon using 27343-1-AP (same clone as 27343-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 27343-1-AP (SOCS6 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27343-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of mouse colon tissue using SOCS6 Polyclonal antibody (27343-1-AP)

    IHC staining of mouse colon using 27343-1-AP (same clone as 27343-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse colon tissue slide using 27343-1-AP (SOCS6 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27343-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of mouse colon tissue using SOCS6 Polyclonal antibody (27343-1-AP)

    IHC staining of mouse colon using 27343-1-AP (same clone as 27343-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse colon tissue slide using 27343-1-AP (SOCS6 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27343-1-PBS in a different storage buffer formulation.

SOCS6 Polyclonal antibody, PBS Only

SOCS6 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 27343-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IHC, IP, Indirect ELISA

Synonyms

CIS 4, CIS4, CIS-4, Cytokine-inducible SH2 protein 4, HSPC060

Formulation:  PBS Only
PBS, Azide, Glycerol
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

27343-1-PBS targets SOCS6 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen

CatNo: Ag25594

Product name: Recombinant human SOCS6 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 132-385 aa of BC020082

Sequence: YSPAPWPLRPTNSEETCIKMEVRVKALVHSSSPSPALNGVRKDFHDLQSETTCQEQANSLKSSASHNGDLHLHLDEHVPVVIGLMPQDYIQYTVPLDEGMYPLEGSRSYCLDSSSPMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTGVMLQSPRAGHDDVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWY

相同性解析による交差性が予測される生物種
Full Name suppressor of cytokine signaling 6
Calculated molecular weight 60 kDa
Observed molecular weight 60-75 kDa
GenBank accession numberBC020082
Gene Symbol SOCS6
Gene ID (NCBI) 9306
Conjugate Unconjugated
Form
FormLiquid
Purification MethodAntigen affinity purification
UNIPROT IDO14544
Storage Buffer PBS only{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -80°C.

Background Information

SOCS6 (Suppressor of cytokine signaling 6) is also named as CIS4 and SOCS4. SOCS6 is one of eight members of the SOCS family of proteins. SOCS6 is involved in negative regulation of receptor signaling by increasing degradation mediated by ubiquitination of receptors or substrate proteins and induces apoptosis by targeting mitochondrial proteins (PMID: 25172101). SOCS6 is widely expressed in many tissues and is found to be downregulated in many cancers including colorectal cancer, gastric cancer, lung cancer, ovarian cancer, stomach cancer, thyroid cancer, hepatocellular carcinoma, and pancreatic cancer (PMID: 25172101). In addition to its molecular weight of 60 kDa, SOCS6 has a 70 kDa isoform (PMID: 34169835, PMID: 22125600).

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