Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
11737-1-PBS targets SNX2 in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.
| Tested Reactivity | human, mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag2259 Product name: Recombinant human SNX2 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 171-520 aa of BC003382 Sequence: SMFSKSEFSVKRRFSDFLGLHSKLASKYLHVGYIVPPAPEKSIVGMTKVKVGKEDSSSTEFVEKRRAALERYLQRTVKHPTLLQDPDLRQFLESSELPRAVNTQALSGAGILRMVNKAADAVNKMTIKMNESDAWFEEKQQQFENLDQQLRKLHVSVEALVCHRKELSANTAAFAKSAAMLGNSEDHTALSRALSQLAEVEEKIDQLHQEQAFADFYMFSELLSDYIRLIAAVKGVFDHRMKCWQKWEDAQITLLKKREAEAKMMVANKPDKIQQAKNEIREWEAKVQQGERDFEQISKTIRKEVGRFEKERVKDFKTVIIKYLESLVQTQQQLIKYWEAFLPEAKAIA 相同性解析による交差性が予測される生物種 |
| Full Name | sorting nexin 2 |
| Calculated molecular weight | 519 aa, 58 kDa |
| Observed molecular weight | ~70 kda |
| GenBank accession number | BC003382 |
| Gene Symbol | SNX2 |
| Gene ID (NCBI) | 6643 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | O60749 |
| Storage Buffer | PBS only{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
Sorting nexin 2 (SNX2) belongs to the sorting nexin family, characterized by the presence of a phox (PX) domain that binds phosphoinositides and mediates intracellular trafficking. It regulates the cell-surface expression and degradation of epidermal growth factor receptor (EGFR) through endosomal sorting (PMID: 14978220). SNX2 also participates in retrograde transport from endosomes to the trans-Golgi network and maintains cellular homeostasis (PMID: 38033809).