Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
29372-1-PBS targets SLC6A19 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag31076 Product name: Recombinant human SLC6A19 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 142-192 aa of BC148801 Sequence: NSFQEPLPWSDCPLNENQTGYVDECARSSPVDYFWYRETLNISTSISDSGS 相同性解析による交差性が予測される生物種 |
| Full Name | solute carrier family 6 (neutral amino acid transporter), member 19 |
| Calculated molecular weight | 634 aa, 71 kDa |
| Observed molecular weight | 70 kDa |
| GenBank accession number | BC148801 |
| Gene Symbol | SLC6A19 |
| Gene ID (NCBI) | 340024 |
| RRID | AB_2918286 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q695T7 |
| Storage Buffer | PBS only{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
SLC6A19, also named as B0AT1, encodes system B(0) transmembrane protein that mediates epithelial resorption of neutral amino acids across the apical membrane in kidney and intestine (PubMed: 15044460). The protein contains 634 amino acids and has 12 predicted transmembrane regions with highly expression in human kidney and small intestine and minimal in pancreas (PubMed: 15286787). The expression of SLC6A19 in intestinal cells depends on angiotensin converting enzyme 2 which is the cellular receptor for SARS-CoV-2 (PubMed: 32132184). Mutations in SLC6A19 cause Hartnup disease (PMID: 15286787, PMID: 15286788).