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Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
55442-1-PBS targets SLC12A3/NCCT in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.
| Tested Reactivity | human, mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
Peptide 相同性解析による交差性が予測される生物種 |
| Full Name | solute carrier family 12 (sodium/chloride transporters), member 3 |
| Calculated molecular weight | 114 kDa |
| Observed molecular weight | 150 kDa |
| GenBank accession number | NM_000339 |
| Gene Symbol | SLC12A3 |
| Gene ID (NCBI) | 6559 |
| RRID | AB_3743209 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P55017 |
| Storage Buffer | PBS only{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
SLC12A3 also known as NCCT, NCC, is a sodium-chloride cotransporter (NCC), which mainly functions in the distal convoluted tubules of the kidney and is responsible for the reabsorption of sodium ions and chloride ions (PMID: 35591852). This cotransporter is the target of thiazide diuretics used in the treatment of hypertension. Mutations in SLC12A3 cause Gitelman syndrome(PMID: 8528245, 33462018).