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Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using SFMBT1 Polyclonal antibody (23631-1-AP)

    WB analysis using 23631-1-AP

    Various lysates were subjected to SDS PAGE followed by western blot with 23631-1-AP (SFMBT1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours.

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SFMBT1 Polyclonal antibody

SFMBT1 Polyclonal Antibody for WB, ELISA
Cat No. 23631-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, ELISA

Synonyms

RU1, SFMBT, SFMBT 1

Formulation:  PBS and Azide
PBS and Azide
Conjugate:  Unconjugated
Unconjugated
Size/Concentration: 

-/ -

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テクニカルサポートまたはご購入後1年間の交換／補填対応を承ります。詳細はこちらをご覧ください。

Tested Applications

Positive WB detected inIMR-32 cells, mouse testis tissue, rat testis tissue

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:6000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

23631-1-AP targets SFMBT1 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen SFMBT1 fusion protein Ag20417 相同性解析による交差性が予測される生物種
Full Name Scm-like with four mbt domains 1
Calculated molecular weight 866 aa, 98 kDa
Observed molecular weight 93-98 kDa
GenBank accession numberBC014614
Gene Symbol SFMBT1
Gene ID (NCBI) 51460
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen Affinity purified
UNIPROT IDQ9UHJ3
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

Scm-like with four MBT domains protein 1 (SFMBT1) is also named as Renal ubiquitous protein 1 (RU1). SFMBT1 is a transcriptional repressor that associates with chromatin and interacts with the N-terminal tail of histone H3 (PMID: 17599839). SFMBT1 forms a complex with Lys-specific demethylase 1 (LSD1) and they are believed to act together in combination with RNA polymerase II in the transcriptional regulation of histone genes (PMID: 23592795). SFMBT1 is up-regulated in CRC tumor tissues and cells and may be associated with drug resistance (PMID: 35577773). SFMBT1 regulates the expression and interacts with key genes involved in heart muscle and artery development (PWWP2A, as well as myogenic differentiation (MYOD, SIX2) (PMID: 35483874). Testes, endocrine glands, and blood are tissues that highly express SFMBT1 (PMID: 25613900). SFMBT1 is also highly expressed in skeletal muscles specifically in undifferentiated myoblasts, and this expression starts diminishing during muscle differentiation (PMID: 23349461).

Protocols

Product Specific Protocols
WB protocol for SFMBT1 antibody 23631-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols