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Validation Data Gallery

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  • Western Blot (WB) analysis of HepG2 cells using SDSL Polyclonal antibody (16242-1-AP)

    WB analysis of HepG2 using 16242-1-AP

    HepG2 cells were subjected to SDS PAGE followed by western blot with 16242-1-AP (SDSL antibody) at dilution of 1:700 incubated at room temperature for 1.5 hours.

  • Western Blot (WB) analysis of human liver tissue using SDSL Polyclonal antibody (16242-1-AP)

    WB analysis of human liver using 16242-1-AP

    human liver tissue were subjected to SDS PAGE followed by western blot with 16242-1-AP (SDSL antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

  • Western Blot (WB) analysis of human liver tissue using SDSL Polyclonal antibody (16242-1-AP)

    WB analysis of human liver using 16242-1-AP

    human liver tissue were subjected to SDS PAGE followed by western blot with 16242-1-AP (SDSL antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

  • Western Blot (WB) analysis of human colon tissue using SDSL Polyclonal antibody (16242-1-AP)

    WB analysis of human colon using 16242-1-AP

    human colon tissue were subjected to SDS PAGE followed by western blot with 16242-1-AP (SDSL antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

  • Western Blot (WB) analysis of mouse liver tissue using SDSL Polyclonal antibody (16242-1-AP)

    WB analysis of mouse liver using 16242-1-AP

    mouse liver tissue were subjected to SDS PAGE followed by western blot with 16242-1-AP (SDSL antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

  • Western Blot (WB) analysis of mouse lung tissue using SDSL Polyclonal antibody (16242-1-AP)

    WB analysis of mouse lung using 16242-1-AP

    mouse lung tissue were subjected to SDS PAGE followed by western blot with 16242-1-AP (SDSL antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

  • Immunohistochemistry (IHC) staining of human liver tissue using SDSL Polyclonal antibody (16242-1-AP)

    IHC staining of human liver using 16242-1-AP

    Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 16242-1-AP (SDSL antibody) at dilution of 1:2000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • Immunohistochemistry (IHC) staining of human liver tissue using SDSL Polyclonal antibody (16242-1-AP)

    IHC staining of human liver using 16242-1-AP

    Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 16242-1-AP (SDSL antibody) at dilution of 1:2000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • Immunohistochemistry (IHC) staining of mouse liver tissue using SDSL Polyclonal antibody (16242-1-AP)

    IHC staining of mouse liver using 16242-1-AP

    Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 16242-1-AP (SDSL antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • Immunohistochemistry (IHC) staining of mouse liver tissue using SDSL Polyclonal antibody (16242-1-AP)

    IHC staining of mouse liver using 16242-1-AP

    Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 16242-1-AP (SDSL antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • Immunofluorescence (IF) / fluorescent staining of HepG2 cells using SDSL Polyclonal antibody (16242-1-AP)

    IF Staining of HepG2 using 16242-1-AP

    Immunofluorescent analysis of (-20°C Ethanol) fixed HepG2 cells using SDSL antibody (16242-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2).

SDSL Polyclonal antibody

SDSL Polyclonal Antibody for WB, IHC, IF/ICC, ELISA
Cat No. 16242-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IHC, IF/ICC, ELISA

Synonyms

EC:4.3.1.17, EC:4.3.1.19, L serine deaminase, L threonine dehydratase, L-serine deaminase

Formulation:  PBS, Azide, Glycerol
PBS, Azide, Glycerol
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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テクニカルサポートまたはご購入後1年間の交換／補填対応を承ります。詳細はこちらをご覧ください。

Tested Applications

Positive WB detected inHepG2 cells, human colon tissue, human liver tissue, mouse liver tissue, mouse lung tissue
Positive IHC detected inhuman liver tissue, mouse liver tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF/ICC detected inHepG2 cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:3000
Immunohistochemistry (IHC)IHC : 1:1000-1:4000
Immunofluorescence (IF)/ICCIF/ICC : 1:200-1:800
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

16242-1-AP targets SDSL in WB, IHC, IF/ICC, ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen

CatNo: Ag9114

Product name: Recombinant human SDSL protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-167 aa of BC009849

Sequence: MDGPVAEHAKQEPFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLVCSSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQELAKRDGWENVPPFDHPLIWKGHASLVQELKAVLRTPPG

相同性解析による交差性が予測される生物種
Full Name serine dehydratase-like
Calculated molecular weight 329 aa, 35 kDa
Observed molecular weight 55 kDa
GenBank accession numberBC009849
Gene Symbol SDSL
Gene ID (NCBI) 113675
RRIDAB_2254163
Conjugate Unconjugated
Form
FormLiquid
Purification MethodAntigen affinity purification
UNIPROT IDQ96GA7
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

SDSL (full name: Serine Dehydratase-Like) is a pyridoxal phosphate (PLP)-dependent enzyme encoded by human SDSL gene, which is mainly located in cytoplasm. Biochemical activity: It is a multifunctional enzyme with weak L- serine ammonia-lyase and L- threonine dehydratase activities, and participates in the process of amino acid catabolism (catalyzing serine and threonine to be converted into pyruvate, α-ketobutyric acid and ammonia respectively). Studies have shown that compared with the homologous enzyme SDS in the liver, the activity of SDSL in human cancer cells is lower. Clinical and research significance: This protein plays a certain role in signal transduction and metabolic regulation. Abnormal expression or variation at the gene level is related to specific genetic diseases (such as some thyroid dysfunction) and cancer mechanism research. Homodimer can be formed.

Protocols

Product Specific Protocols
IF protocol for SDSL antibody 16242-1-APDownload protocol
IHC protocol for SDSL antibody 16242-1-APDownload protocol
WB protocol for SDSL antibody 16242-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols
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