Recombinant Rat gp130/IL6ST protein (His Tag)
Species
Rat
Purity
>90 %, SDS-PAGE
Tag
His Tag
Activity
not tested
Cat no : Eg0857
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <1.0 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Rat gp130/IL6ST protein Gln23-Glu618 (Accession# H9BFG4) with a His tag at the C-terminus. |
| GeneID | 25205 |
| Accession | H9BFG4 |
| PredictedSize | 68.0 kDa |
| SDS-PAGE | |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
GP130, also known as IL6ST, is a transmembrane protein that serves as a shared signal-transducing subunit for a variety of cytokines, including interleukin-6 (IL-6), IL-11, IL-27, leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), oncostatin M (OSM), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine (CLC)/CLC factor 1 (CLCF-1), and neuropoietin. This protein is highly conserved among vertebrates and plays a crucial role in mediating interactions between a wide range of immune and non-immune cells. GP130 was originally discovered in 1978 and was successfully cloned and expressed in 1990, leading to a deeper understanding of cytokine signaling pathways.
References:
1. Osman, Essam Eldin A, and Nouri Neamati. Pharmacological reviews vol. 76,6 (2024): 1399-1443. 2. Xu, Shili, and Nouri Neamati. Expert opinion on therapeutic targets vol. 17,11 (2013): 1303-28. 3. Andersson, L C et al. Proceedings of the National Academy of Sciences of the United States of America vol. 75,7 (1978): 3455-8.