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Recombinant Rat TrkA protein (rFc Tag) (HPLC verified)

Species

Rat

Purity

>90 %, SDS-PAGE
>90 %, SEC-HPLC

Tag

rFc Tag

Activity

not tested

Cat no : Eg3210

Validation Data Gallery

  • Purity of Recombinant Rat TrkA was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Rat TrkA was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Rat TrkA was greater than 90% as determined by SEC-HPLC.

    The purity of Rat TrkA was greater than 90% as determined by SEC-HPLC.

Product Information

Purity >90 %, SDS-PAGE
>90 %, SEC-HPLC
Endotoxin <0.1 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Rat TrkA protein Ala33-Pro418 (Accession# P35739-1) with a rabbit IgG Fc tag at the C-terminus.
GeneID 59109
Accession P35739-1
PredictedSize 68.5 kDa
SDS-PAGE 80-120 kDa, reducing (R) conditions
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

TrkA belongs to the Trk receptor family, which plays a central role in a very broad range of cellular responses and is implicated in a spectrum of human pathologies, including Alzheimer’s, Parkinson’s diseases, pain, and notably cancer. TrkA in particular was first to be identified as a specific receptor for NGF and is activated upon NGF binding.

References:

1. Zhao S, et al. (2020). Commun Biol. 3(1):706.
2. Kaplan DR, et al. (1991). Nature. 350:158–160.
3. Klein R, et al. (1991). Cell. 65:189–197.
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