Recombinant Rat Serpin A12/Vaspin protein (rFc Tag)
Species
Rat
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg3407
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | CHO-derived Rat Serpin A12 protein Leu21-Pro411 (Accession# Q8R4Z1) with a rabbit IgG Fc tag at the N-terminus. |
| GeneID | 191570 |
| Accession | Q8R4Z1 |
| PredictedSize | 72.3 kDa |
| SDS-PAGE | 68-85 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
SERPINA12 is also named as Serpin A12 and Visceral adipose tissue-derived serine protease inhibitor (Vaspin). Vaspin is an adipokine belonging to the serpin family, thus also named SERPINA12, with targets in kallikrein 7 and 14 that participates in skin desquamation. Vaspin is a compensatory molecule in obesity and insulin resistance. Vaspin is a newly described adipokine with an insulin sensitizing effect and inhibitory impact on food intake.
References:
1. Kurowska, Patrycja et al. Cells vol.10,71710.6Jul.2021 2. Wada,Jun. Expert opinion on investigational drugs vol.17,3(2008):327-33. 3. Hida, Kazuyukiet al. Proceedings of the National Academy of Sciences of the United States of America vol.102,30(2005): 10610-5. 4. Klöting, N et al. Diabetologia vol.54,7(2011):1819-23.