Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
16802-1-PBS targets RNF26 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag10285 Product name: Recombinant human RNF26 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 239-433 aa of BC000058 Sequence: AVTVTVLHPDFTLRLATQALSQLHARPSYHRLREDVMRLSRLALGSEAWRRVWSRSLQLASWPNRGGAPGAPQGDPMRVFSVRTRRQDTLPEAGRRSEAEEEEARTIRVTPVRGRERLNEEEPPGGQDPWKLLKEQEERKKCVICQDQSKTVLLLPCRHLCLCQACTEILMRHPVYHRNCPLCRRGILQTLNVYL 相同性解析による交差性が予測される生物種 |
| Full Name | ring finger protein 26 |
| Calculated molecular weight | 433 aa, 48 kDa |
| Observed molecular weight | 48 kDa |
| GenBank accession number | BC000058 |
| Gene Symbol | RNF26 |
| Gene ID (NCBI) | 79102 |
| RRID | AB_2878317 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q9BY78 |
| Storage Buffer | PBS only{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
RNF26 is concentrated predominantly in the PN segment of the ER membrane, which corresponds with its ability to position all endosomal vesicles in the PN region of the cell. RNF26 resides in the perinuclear ER membrane, and this feature enables it to spatially restrict various endolysosomal species by attracting ubiquitin-binding vesicle adaptors through a ubiquitindependent ER MCS. RNF26 is an important E3 ubiquitin ligase that has been associated with poor prognosis in bladder cancer. And RNF26 is prevalent in normal human tissues but is upregulated in several human tumor cell lines (HL-60, HeLa S3 and SW480) (PMID: 33472082, 37519262).