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Validation Data Gallery

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  • Western Blot (WB) analysis of Raji cells using RBBP8 Polyclonal antibody (12624-1-AP)

    WB analysis of Raji using 12624-1-AP (same clone as 12624-1-PBS)

    Raji cells were subjected to SDS PAGE followed by western blot with 12624-1-AP (RBBP8 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12624-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of A431 cells using RBBP8 Polyclonal antibody (12624-1-AP)

    WB analysis of A431 using 12624-1-AP (same clone as 12624-1-PBS)

    A431 cells were subjected to SDS PAGE followed by western blot with 12624-1-AP (RBBP8 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12624-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

RBBP8 Polyclonal antibody, PBS Only

RBBP8 Polyclonal Antibody for WB, Indirect ELISA
Cat No. 12624-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, Indirect ELISA

Synonyms

Formulation:  PBS Only
PBS, Azide, Glycerol
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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テクニカルサポートまたはご購入後1年間の交換／補填対応を承ります。詳細はこちらをご覧ください。

Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

12624-1-PBS targets RBBP8 in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen

CatNo: Ag3314

Product name: Recombinant human RBBP8 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 604-902 aa of BC030590

Sequence: KSAGSHEPIKIQTRSDHGGCELASVLQLNPCRTGKIKSLQNNQDVSFENIQWSIDPGADLSQYKMDVTVIDTKDGSQSKLGGETVDMDCTLVSETVLLKMKKQEQKGEKSSMLFYIDEERKMNDSLEDMFDRTTHEEYESCLADSFSQAADEEEELSTATKKLHTHGDKQDKVKQKAFVEPYFKGDERETSLQNFPHIEVVRKKEERRKLLGHTCKECEIYYADMPAEEREKKLASCSRHRFRYIPPNTPENFWEVGFPSTQTCMERGYIKEDLDPCPRPKRRQPYNAIFSPKGKEQKT

相同性解析による交差性が予測される生物種
Full Name retinoblastoma binding protein 8
Calculated molecular weight 103 kDa
Observed molecular weight 120 kDa
GenBank accession numberBC030590
Gene Symbol RBBP8
Gene ID (NCBI) 5932
RRIDAB_2175250
Conjugate Unconjugated
Form
FormLiquid
Purification MethodAntigen affinity purification
UNIPROT IDQ99708
Storage Buffer PBS only{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -80°C.

Background Information

RBBP8 is an endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends. It functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. It interacted with BRCA1 to form a complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Also it promotes microhomology-mediated alternative end joining (A-NHEJ) during class-switch recombination and plays an essential role in chromosomal translocations

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