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Validation Data Gallery

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  • Western Blot (WB) analysis of HeLa cells using QTRT1 Polyclonal antibody (12349-1-AP)

    WB analysis of HeLa using 12349-1-AP

    WB result of QTRT1 antibody (12349-1-AP; 1:1000; incubated at room temperature for 1.5 hours) with sh-Control and sh-QTRT1 transfected HeLa cells.

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QTRT1 Polyclonal antibody

QTRT1 Polyclonal Antibody for WB, ELISA
Cat No. 12349-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Synonyms

EC:2.4.2.64, FP3235, Guanine insertion enzyme, Queuine tRNA-ribosyltransferase catalytic subunit 1, TGT

Formulation:  PBS and Azide
PBS and Azide
Conjugate:  Unconjugated
Unconjugated
Size/Concentration: 

-/ -

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Tested Applications

Positive WB detected inHeLa cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:2000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

12349-1-AP targets QTRT1 in WB, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen QTRT1 fusion protein Ag3010 相同性解析による交差性が予測される生物種
Full Name queuine tRNA-ribosyltransferase 1
Calculated molecular weight 403 aa, 44 kDa
Observed molecular weight 44 kDa
GenBank accession numberBC015350
Gene Symbol QTRT1
Gene ID (NCBI) 81890
RRIDAB_2877847
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ9BXR0
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

QTRT1 (Queuine tRNA-ribosyltransferase catalytic subunit 1), also known as tRNA-guanine transglycosylase (TGT), is a key enzymeinvolved in the post-transcriptional modification of tRNAs. In humans, the QTRT1 and QTRT2 heterodimer complex exhibits transglycosylase activity, and replaces the guanine base of the first letter of the tRNA anticodon with q, thus forming Q on the tRNA (PMID: 30149595, 25884661). High QTRT1 expression is a biomarkerfor poor prognosis in LUAD patients, and QTRT1 mayfunction as a latent tumor biomarker in the prognosticprediction for LUAD (PMID: 33490170).

Protocols

Product Specific Protocols
WB protocol for QTRT1 antibody 12349-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols