Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
68394-1-PBS targets Protein Z in WB, Indirect ELISA applications and shows reactivity with Human samples.
| Tested Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag13051 Product name: Recombinant human PROZ protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 23-400 aa of BC074906 Sequence: SVFLPASKANDVLVRWKRAGSYLLEELFEGNLEKECYEEICVYEEAREVFENEVVTDEFWRRYKGGSPCISQPCLHNGSCQDSIWGYTCTCSPGYEGSNCELAKNECHPERTDGCQHFCLPGQESYTCSCAQGYRLGEDHKQCVPHDQCACGVLTSEKRAPDLQDLPWQVKLTNSEGKDFCGGVIIRENFVLTTAKCSLLHRNITVKTYFNRTSQDPLMIKITHVHVHMRYDADAGENDLSLLELEWPIQCPGAGLPVCTPEKDFAEHLLIPRTRGLLSGWARNGTDLGNSLTTRPVTLVEGEECGQVLNVTVTTRTYCERSSVAAMHWMDGSVVTREHRGSWFLTGVLGSQPVGGQAHMVLVTKVSRYSLWFKQIMN 相同性解析による交差性が予測される生物種 |
| Full Name | protein Z, vitamin K-dependent plasma glycoprotein |
| Calculated molecular weight | 400 aa, 45 kDa |
| Observed molecular weight | 45-47 kDa, 27 kDa |
| GenBank accession number | BC074906 |
| Gene Symbol | PROZ |
| Gene ID (NCBI) | 8858 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | P22891 |
| Storage Buffer | PBS only{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
Protein Z (PZ, PROZ) is a vitamin K-dependent plasma protein that serves as a cofactor for activated factor X inhibition by the PZ-dependent protease inhibitor (PMID: 16938126). Reduced circulating levels of PZ have been suggested to play a role in the occurrence of bleeding (PMID: 7495103) and deep vein thrombosis (DVT) (PMID: 10829076), as well as in unexplained abortions with early fetal loss (PMID: 11895801), late fetal demise and intrauterine growth restriction (PMID: 16260213), acute coronary syndromes (PMID: 14652653), and stroke (PMID: 11570404). In addition, PZ may be a biomarker for the early diagnosis of pancreatic cancer (PMID: 31025496). It has two isoforms with molecular weights of 44 kDa and 47 kDa.