Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
88056-2-PBS targets Prosaposin receptor GPR37 in WB, Indirect ELISA applications and shows reactivity with mouse samples.
| Tested Reactivity | mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
CatNo: Eg10256 Product name: Recombinant mouse Prosaposin receptor GPR37 protein Source: mammalian cells-derived, V37 Tag: C-rFc Domain: 27-252 aa of NM_010338.2 Sequence: ALSFVPEPRNGTCLGESCSPLIQRRSRDARGPGNSAKDALRVHVPREKLEAEVRGATSWDLPPPRGGDTGVIEEAAAAGPLGPPTKPPSAWRWKSAQGKEPSGHLRRRDPTDPQLFFPTSEGGEMSSKRDGIPQSRQEHSVKTEPRDLFYWPRRTGQLQDSQHRPSAVHEGRTLAPPGRALPQNGSADDWVPDQGGPRRGNTTRRVRLKNPFYPLTQESYGAYAVM 相同性解析による交差性が予測される生物種 |
| Full Name | G protein-coupled receptor 37 |
| Calculated molecular weight | 67 kDa |
| Observed molecular weight | 50 kDa |
| GenBank accession number | NM_010338.2 |
| Gene Symbol | Gpr37 |
| Gene ID (NCBI) | 14763 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | Q9QY42-1 |
| Storage Buffer | PBS only{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
G protein-coupled receptor 37 (GPR37), also known as the prosaposin receptor, is a class A GPCR predominantly expressed in the central nervous system, especially in oligodendrocytes and select neuronal populations. GPR37 has been identified as a receptor for prosaposin and prosaptide peptides, mediating neuroprotective and glioprotective signaling. In mice, Gpr37 plays important roles in oligodendrocyte differentiation, myelination, and cellular stress responses, as well as modulation of dopaminergic signaling pathways. Functionally, GPR37 is involved in cell survival, ER stress regulation, and protein quality control, and has been linked to Parkinson's disease-related mechanisms, including its interaction with parkin (PARK2) and propensity to form intracellular aggregates under pathological conditions.