Recombinant Pig IL-1 beta protein (rFc Tag)
Species
Pig
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg4869
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Pig IL-1 beta protein Ala115-Pro267 (Accession# P26889) with a rabbit IgG Fc tag at the N-terminus. |
| GeneID | 397122 |
| Accession | P26889 |
| PredictedSize | 44.8 kDa |
| SDS-PAGE | 45-52 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
Interleukin 1β (IL-1B) is a member of the interleukin 1 cytokine family. It is a pro-inflammatory cytokine against infection, playing an important role in the pathogenesis of cancers. It signals through various adaptor proteins and kinases that lead to activation of numerous downstream targets.
References:
1. Takada YK. et al. (2017) J Biol Chem. 292: 20067-20075. 2. LaRock DL. et al. (2020) Infect Immun. 88: e00356-20. 3. Tian XX. et al. (2021) Int Endod J. 54: 916-925. 4. Jourdan T. et al. (2013) Nat Med. 19: 1132-1140.