Validation Data Gallery
Filter:
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
87289-1-PBS targets Phospho-LAT (Tyr220) in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
Peptide 相同性解析による交差性が予測される生物種 |
| Full Name | linker for activation of T cells |
| Calculated molecular weight | 262 aa, 28 kDa |
| Observed molecular weight | 36 kDa, 38 kDa |
| GenBank accession number | BC011563 |
| Gene Symbol | LAT |
| Gene ID (NCBI) | 27040 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | O43561 |
| Storage Buffer | PBS only{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
LAT is a membrane-localized adaptor protein which is primarily concentrated in microdomains by palmitoylation. Phospho-LAT (Tyr220) is a phosphorylated form of the Linker for Activation of T cells (LAT), a protein that plays a pivotal role in T cell receptor (TCR) signaling. LAT is involved in the assembly of the signaling complex that leads to T cell activation. Upon TCR engagement, LAT becomes phosphorylated at multiple tyrosine residues, including Tyr220. (PMID: 38746248)