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Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
82816-4-PBS targets Phospho-AXL (Tyr779) in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
Peptide 相同性解析による交差性が予測される生物種 |
| Full Name | AXL receptor tyrosine kinase |
| Calculated molecular weight | 894 aa, 98 kDa |
| Observed molecular weight | 140 kDa |
| GenBank accession number | BC032229 |
| Gene Symbol | AXL |
| Gene ID (NCBI) | 558 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | P30530 |
| Storage Buffer | PBS only{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
Axl, also known as Ufo or Ark, is a receptor tyrosine kinase of the TAM (Tyro3, Axl and Mer) family. Phospho-AXL (Tyr779) refers to the phosphorylated form of the receptor tyrosine kinase AXL at tyrosine 779 within its intracellular kinase domain. Upon ligand binding (e.g., Gas6 or HGF), AXL dimerizes and undergoes trans-autophosphorylation, generating phospho-Tyr779 that serves as a docking site for the p85 regulatory subunit of PI3K, thereby activating the PI3K/AKT/mTOR pathway and promoting cell survival, migration, and invasion. (PMID: 28251492)